Histamie release in vitro: Inhibition by catecholamines and methylxanthines

L. M. Lichtenstein, S. Margolis

Research output: Contribution to journalArticlepeer-review

331 Scopus citations


Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3′,5′- adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.

Original languageEnglish (US)
Pages (from-to)902-903
Number of pages2
Issue number3844
StatePublished - 1968

ASJC Scopus subject areas

  • General


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