Histamie release in vitro: Inhibition by catecholamines and methylxanthines

L. M. Lichtenstein; S. Margolis

doi:10.1126/science.161.3844.902

Histamie release in vitro: Inhibition by catecholamines and methylxanthines

L. M. Lichtenstein, S. Margolis

School of Medicine

Research output: Contribution to journal › Article › peer-review

331 Scopus citations

Abstract

Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3′,5′- adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.

Original language	English (US)
Pages (from-to)	902-903
Number of pages	2
Journal	Science
Volume	161
Issue number	3844
DOIs	https://doi.org/10.1126/science.161.3844.902
State	Published - 1968

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title = "Histamie release in vitro: Inhibition by catecholamines and methylxanthines",

abstract = "Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3′,5′- adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.",

author = "Lichtenstein, {L. M.} and S. Margolis",

year = "1968",

doi = "10.1126/science.161.3844.902",

language = "English (US)",

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AU - Lichtenstein, L. M.

AU - Margolis, S.

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AB - Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3′,5′- adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.

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Histamie release in vitro: Inhibition by catecholamines and methylxanthines

Abstract

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