Higher levels of a cytotoxic protein, vaginolysin, in lactobacillus-deficient community state types at the vaginal mucosa

Rebecca G. Nowak; Tara M. Randis; Purnahamsi Desai; Xin He; Courtney K. Robinson; Jessica M. Rath; Elbert D. Glover; Adam J. Ratner; Jacques Ravel; Rebecca M. Brotman

doi:10.1097/OLQ.0000000000000774

Higher levels of a cytotoxic protein, vaginolysin, in lactobacillus-deficient community state types at the vaginal mucosa

Rebecca G. Nowak, Tara M. Randis, Purnahamsi Desai, Xin He, Courtney K. Robinson, Jessica M. Rath, Elbert D. Glover, Adam J. Ratner, Jacques Ravel, Rebecca M. Brotman

Research output: Contribution to journal › Article › peer-review

Abstract

Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.

Original language	English (US)
Pages (from-to)	e14-e17
Journal	Sexually transmitted diseases
Volume	45
Issue number	4
DOIs	https://doi.org/10.1097/OLQ.0000000000000774
State	Published - Apr 1 2018
Externally published	Yes

ASJC Scopus subject areas

Dermatology
Public Health, Environmental and Occupational Health
Microbiology (medical)
Infectious Diseases

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10.1097/OLQ.0000000000000774

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title = "Higher levels of a cytotoxic protein, vaginolysin, in lactobacillus-deficient community state types at the vaginal mucosa",

abstract = "Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.",

author = "Nowak, {Rebecca G.} and Randis, {Tara M.} and Purnahamsi Desai and Xin He and Robinson, {Courtney K.} and Rath, {Jessica M.} and Glover, {Elbert D.} and Ratner, {Adam J.} and Jacques Ravel and Brotman, {Rebecca M.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 by the American Sexually Transmitted Diseases Association. Unauthorized reproduction of this article is prohibited.",

year = "2018",

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doi = "10.1097/OLQ.0000000000000774",

language = "English (US)",

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T1 - Higher levels of a cytotoxic protein, vaginolysin, in lactobacillus-deficient community state types at the vaginal mucosa

AU - Nowak, Rebecca G.

AU - Randis, Tara M.

AU - Desai, Purnahamsi

AU - He, Xin

AU - Robinson, Courtney K.

AU - Rath, Jessica M.

AU - Glover, Elbert D.

AU - Ratner, Adam J.

AU - Ravel, Jacques

AU - Brotman, Rebecca M.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.

AB - Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.

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Higher levels of a cytotoxic protein, vaginolysin, in lactobacillus-deficient community state types at the vaginal mucosa

Abstract

ASJC Scopus subject areas

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