Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states

Chuan V. Dang; Chi V. Dang

doi:10.1007/BF00214769

Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states

Chuan V. Dang, Chi V. Dang

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5′, 5′′′-P¹, P⁴-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.

Original language	English (US)
Pages (from-to)	107-120
Number of pages	14
Journal	Molecular and Cellular Biochemistry
Volume	71
Issue number	2
DOIs	https://doi.org/10.1007/BF00214769
State	Published - Aug 1986
Externally published	Yes

Keywords

aging
amino acid transport
aminoacyl-tRNA synthetase
diadenosine tetraphosphate
hormones
myositis
neoplasia
ontogenesis
protein synthesis
starvation

ASJC Scopus subject areas

Molecular Biology
Clinical Biochemistry
Cell Biology

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10.1007/BF00214769

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title = "Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states",

abstract = "The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5′, 5′′′-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.",

keywords = "aging, amino acid transport, aminoacyl-tRNA synthetase, diadenosine tetraphosphate, hormones, myositis, neoplasia, ontogenesis, protein synthesis, starvation",

author = "Dang, {Chuan V.} and Dang, {Chi V.}",

year = "1986",

month = aug,

doi = "10.1007/BF00214769",

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T1 - Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states

AU - Dang, Chuan V.

AU - Dang, Chi V.

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N2 - The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5′, 5′′′-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.

AB - The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5′, 5′′′-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.

KW - aging

KW - amino acid transport

KW - aminoacyl-tRNA synthetase

KW - diadenosine tetraphosphate

KW - hormones

KW - myositis

KW - neoplasia

KW - ontogenesis

KW - protein synthesis

KW - starvation

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DO - 10.1007/BF00214769

M3 - Review article

C2 - 3534543

AN - SCOPUS:0022764347

SN - 0300-8177

VL - 71

SP - 107

EP - 120

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

IS - 2

ER -

Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states

Abstract

Keywords

ASJC Scopus subject areas

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