High throughput screening technologies for ion channels

Hai Bo Yu, Min Li, Wei Ping Wang, Xiao Liang Wang

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Ion channels are involved in a variety of fundamental physiological processes, and their malfunction causes numerous human diseases. Therefore, ion channels represent a class of attractive drug targets and a class of important off-targets for in vitro pharmacological profiling. In the past decades, the rapid progress in developing functional assays and instrumentation has enabled high throughput screening (HTS) campaigns on an expanding list of channel types. Chronologically, HTS methods for ion channels include the ligand binding assay, flux-based assay, fluorescence-based assay, and automated electrophysiological assay. In this review we summarize the current HTS technologies for different ion channel classes and their applications.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalActa Pharmacologica Sinica
Issue number1
StatePublished - Jan 1 2016


  • automated electrophysiological assay
  • drug discovery
  • fluorescence-based assay
  • flux-based assay
  • high throughput screening
  • ion channels
  • ligand binding assay

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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