High systemic exposure of pyrazinoic acid has limited antituberculosis activity in murine and rabbit models of tuberculosis

Keyphrases

• Murine Model 100%
• Tuberculosis 100%
• Antituberculosis Activity 100%
• Rabbit Model 100%
• Systemic Exposure 100%
• Pyrazinoic Acid 100%
• Pyrazinamide 65%
• PncA 15%
• Lung 10%
• Acid Concentration 10%
• Host Specificity 10%
• CFU Counts 10%
• Pharmacokinetics 5%
• Most Common Cause 5%
• Dose-ranging 5%
• Infection Site 5%
• Balb C Mice 5%
• Orally Administered 5%
• Prodrug 5%
• Null mutant 5%
• Infected Mice 5%
• Effective Strategies 5%
• Area under the Concentration-time Curve 5%
• In Vitro Activity 5%
• Resistant mutants 5%
• Acid Exposure 5%
• Epithelial Lining Fluid 5%
• Systemic Delivery 5%
• Amidase 5%
• Pyrazinamide Resistance 5%
• Acid Value 5%

Immunology and Microbiology

• Mouse 100%
• Murine 100%
• Rabbit Model 100%
• Blood Plasma 75%
• Colony-Forming Unit 50%
• Colony Forming Unit S 50%
• C3HeB/Fe Mouse 50%
• Body Weight 25%
• Bagg Albino Mouse 25%
• Bactericidal Activity 25%
• Pharmacokinetics 25%
• Epithelial Lining Fluid 25%
• Amidase 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Rabbit Model 100%
• Murine 100%
• Pyrazinoic Acid 100%
• Pyrazinamide 70%
• Mouse 20%
• C3HeB/Fe Mouse 10%
• Infection 5%
• Pharmacokinetics 5%
• Prodrug 5%
• Bagg Albino Mouse 5%
• Amidase 5%