High-Sensitivity Troponin as a Biomarker in Heart Rhythm Disease

Cian P. McCarthy, Omair Yousuf, Alvaro Alonso, Elizabeth Selvin, Hugh Calkins, John W. McEvoy

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to augmenting therapeutic decisions by targeting appropriate pharmacologic and interventional therapies to patients who may benefit most. In this review, we focus on the prognostic role of high-sensitivity cardiac troponin (hs-cTn) assays—which detect subclinical cardiac myocyte damage—in cardiac arrhythmias and their sequelae. We review the current literature on hs-cTn and its impact on various arrhythmia disease states and also provide suggestions for future research in this field. In conclusion, although the utility of hs-cTn assays remains at an investigational stage in cardiac EP, studies to date have suggested value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death (both in the general population and among those with hypertrophic cardiomyopathy).

Original languageEnglish (US)
Pages (from-to)1407-1413
Number of pages7
JournalAmerican Journal of Cardiology
Issue number9
StatePublished - May 1 2017

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'High-Sensitivity Troponin as a Biomarker in Heart Rhythm Disease'. Together they form a unique fingerprint.

Cite this