High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout

F. Garibaldi; R. Accorsi; M. N. Cinti; E. Cisbani; S. Colilli; F. Cusanno; R. Fratoni; F. Giuliani; M. Gricia; R. C. Lanza; S. Lo Meo; M. Lucentini; S. Majewski; R. Pani; R. Pellegrini; F. Santavenere; B. Tsui

doi:10.1109/NSSMIC.2005.1596919

High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout

F. Garibaldi, R. Accorsi, M. N. Cinti, E. Cisbani, S. Colilli, F. Cusanno, R. Fratoni, F. Giuliani, M. Gricia, R. C. Lanza, S. Lo Meo, M. Lucentini, S. Majewski, R. Pani, R. Pellegrini, F. Santavenere, B. Tsui

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Good spatial resolution and high sensitivity are required for detectors to be used for most of the bio-medical research and application (small animal imaging, detection of small tumors,). In this paper we report on parameter optimization of single photon gamma rays detectors. Simulations and measurements were performed for designing and building detectors for early detection of small tumors in breast and in small animal imaging. Critical parameters are: Contrast and Signal to Noise Ratio (SNR). Intrinsic performances (spatial resolution, pixel identification etc.) were optimized first. Arrays of scintillators (NaI(Tl)) of different pixel pitch (down to the present technological limits for NaI(Tl) arrays fabrication (pitch of 2 × 2 mm²,1.5 × 1.5 mm² and 1.2 × 1.2 mm ²)) were coupled to arrays of PSPMTs with two anode readout element dimensions (6 × 6 mm² and 3 × 3 mm²). Detectors having Field Of View of 100 × 100 mm² and 150 × 200 mm² were designed and built. An electronics system for reading out all the anode pad signals has been designed and constructed. Finally the collimation technique was considered. The limits of the coded aperture option have been studied. Preliminary results of these studies are presented.

Original language	English (US)
Title of host publication	2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages	2811-2814
Number of pages	4
DOIs	https://doi.org/10.1109/NSSMIC.2005.1596919
State	Published - Dec 1 2005
Event	Nuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico Duration: Oct 23 2005 → Oct 29 2005

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
Volume	5
ISSN (Print)	1095-7863

Other

Other	Nuclear Science Symposium Conference Record, 2005 IEEE
Country/Territory	Puerto Rico
Period	10/23/05 → 10/29/05

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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10.1109/NSSMIC.2005.1596919

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Garibaldi, F., Accorsi, R., Cinti, M. N., Cisbani, E., Colilli, S., Cusanno, F., Fratoni, R., Giuliani, F., Gricia, M., Lanza, R. C., Lo Meo, S., Lucentini, M., Majewski, S., Pani, R., Pellegrini, R., Santavenere, F., & Tsui, B. (2005). High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout. In 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference (pp. 2811-2814). Article 1596919 (IEEE Nuclear Science Symposium Conference Record; Vol. 5). https://doi.org/10.1109/NSSMIC.2005.1596919

High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout. / Garibaldi, F.; Accorsi, R.; Cinti, M. N. et al.
2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference. 2005. p. 2811-2814 1596919 (IEEE Nuclear Science Symposium Conference Record; Vol. 5).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Garibaldi, F, Accorsi, R, Cinti, MN, Cisbani, E, Colilli, S, Cusanno, F, Fratoni, R, Giuliani, F, Gricia, M, Lanza, RC, Lo Meo, S, Lucentini, M, Majewski, S, Pani, R, Pellegrini, R, Santavenere, F & Tsui, B 2005, High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout. in 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference., 1596919, IEEE Nuclear Science Symposium Conference Record, vol. 5, pp. 2811-2814, Nuclear Science Symposium Conference Record, 2005 IEEE, Puerto Rico, 10/23/05. https://doi.org/10.1109/NSSMIC.2005.1596919

Garibaldi F, Accorsi R, Cinti MN, Cisbani E, Colilli S, Cusanno F et al. High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout. In 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference. 2005. p. 2811-2814. 1596919. (IEEE Nuclear Science Symposium Conference Record). doi: 10.1109/NSSMIC.2005.1596919

Garibaldi, F. ; Accorsi, R. ; Cinti, M. N. et al. / High resolution and high sensitivity detectors for functional molecular imaging with radionuclides : The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout. 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference. 2005. pp. 2811-2814 (IEEE Nuclear Science Symposium Conference Record).

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abstract = "Good spatial resolution and high sensitivity are required for detectors to be used for most of the bio-medical research and application (small animal imaging, detection of small tumors,). In this paper we report on parameter optimization of single photon gamma rays detectors. Simulations and measurements were performed for designing and building detectors for early detection of small tumors in breast and in small animal imaging. Critical parameters are: Contrast and Signal to Noise Ratio (SNR). Intrinsic performances (spatial resolution, pixel identification etc.) were optimized first. Arrays of scintillators (NaI(Tl)) of different pixel pitch (down to the present technological limits for NaI(Tl) arrays fabrication (pitch of 2 × 2 mm2,1.5 × 1.5 mm2 and 1.2 × 1.2 mm 2)) were coupled to arrays of PSPMTs with two anode readout element dimensions (6 × 6 mm2 and 3 × 3 mm2). Detectors having Field Of View of 100 × 100 mm2 and 150 × 200 mm2 were designed and built. An electronics system for reading out all the anode pad signals has been designed and constructed. Finally the collimation technique was considered. The limits of the coded aperture option have been studied. Preliminary results of these studies are presented.",

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High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout

Abstract

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