High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae

Hun Goo Lee; Hyo Soo Lee; Sang Hoon Jeon; Tae Hoon Chung; Young Sung Lim; Won Ki Huh

doi:10.1186/gb-2008-9-1-r2

High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae

Hun Goo Lee
, Hyo Soo Lee
, Sang Hoon Jeon
, Tae Hoon Chung
, Young Sung Lim
, Won Ki Huh

Research output: Contribution to journal › Article › peer-review

Abstract

We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.

Original language	English (US)
Article number	R2
Journal	Genome biology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/gb-2008-9-1-r2
State	Published - Jan 3 2008
Externally published	Yes

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

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10.1186/gb-2008-9-1-r2

Cite this

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abstract = "We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.",

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AU - Lee, Hyo Soo

AU - Jeon, Sang Hoon

AU - Chung, Tae Hoon

AU - Lim, Young Sung

AU - Huh, Won Ki

PY - 2008/1/3

Y1 - 2008/1/3

N2 - We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.

AB - We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.

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UR - https://www.scopus.com/pages/publications/46249096061#tab=citedBy

U2 - 10.1186/gb-2008-9-1-r2

DO - 10.1186/gb-2008-9-1-r2

M3 - Article

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AN - SCOPUS:46249096061

SN - 1474-7596

VL - 9

JO - Genome biology

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M1 - R2

ER -

High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae

Abstract

ASJC Scopus subject areas

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