Abstract
The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends < .01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.
Original language | English (US) |
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Pages (from-to) | 1588-1591 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 212 |
Issue number | 10 |
DOIs | |
State | Published - Nov 15 2015 |
Keywords
- HIV
- Oral HPV
- Oropharyngeal cancer
- Persistence
- Viral load
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases