TY - JOUR
T1 - High-normal fasting blood glucose in non-diabetic range is associated with increased coronary artery calcium burden in asymptomatic men
AU - Nasir, Khurram
AU - Santos, Raul D.
AU - Tufail, Kashif
AU - Rivera, Juan
AU - Carvalho, Jose A.M.
AU - Meneghello, Romeu
AU - Brady, Thomas D.
AU - Blumenthal, Roger S.
N1 - Funding Information:
Khurram Nasir is supported by Grant No. 1T32 HL0761 36-02 from the National Institute of Health, Bethesda, Maryland.
PY - 2007/12
Y1 - 2007/12
N2 - Objective: : The objective of the study is to evaluate whether high fasting blood glucose (FBG) in the non-diabetic range (<126 mg/dl) is associated with subclinical coronary atherosclerosis as determined by coronary artery calcium (CAC) independent of clustering of metabolic syndrome (MS) risk factors. Methods & results: : Previously non-diabetic, 458 asymptomatic non-diabetic Brazilian men (mean age: 46 ± 7 years, range: 29-65) underwent clinical consultation including FBG measurements and electron-beam tomography (EBT). The mean FBG of the study population was 88 ± 10 mg/dl. Overall, 190 (42%) of men had CAC > 0. The prevalence of CAC was significantly higher among men with high-normal FBG (4th quartile: 94-125 mg/dl) versus normal FBG group (lower three quartiles: 66-93 mg/dl) (62% versus 35%, p < 0.0001). In age adjusted analyses the odds ratio (OR) for any CAC among men with high-normal FBG versus normal FBG was 2.19 (95% CI: 1.33-3.58). On further adjustment for risk factors the relationship was slightly attenuated, however remained statistically significant (OR = 1.78, 95% CI 1.05-3.00, p = 0.03). In sub-stratified analyses high-normal FBG was associated with CAC among men without MS (OR: 1.99, 95% CI: 1.04-3.78) and with MS (OR: 2.12, 95% CI: 0.95-4.80). Similar relations with high-normal FBG were observed among individuals classified low risk (OR: 2.34, 95% CI: 1.14-4.83) as well intermediate high-risk men (OR: 1.95, 95% CI: 0.99-3.86) by Framingham risk score (FRS), respectively. Conclusions: : Fasting blood glucose in the upper normal range appears to be associated with the presence of CAC in apparently non-diabetic Brazilian men.
AB - Objective: : The objective of the study is to evaluate whether high fasting blood glucose (FBG) in the non-diabetic range (<126 mg/dl) is associated with subclinical coronary atherosclerosis as determined by coronary artery calcium (CAC) independent of clustering of metabolic syndrome (MS) risk factors. Methods & results: : Previously non-diabetic, 458 asymptomatic non-diabetic Brazilian men (mean age: 46 ± 7 years, range: 29-65) underwent clinical consultation including FBG measurements and electron-beam tomography (EBT). The mean FBG of the study population was 88 ± 10 mg/dl. Overall, 190 (42%) of men had CAC > 0. The prevalence of CAC was significantly higher among men with high-normal FBG (4th quartile: 94-125 mg/dl) versus normal FBG group (lower three quartiles: 66-93 mg/dl) (62% versus 35%, p < 0.0001). In age adjusted analyses the odds ratio (OR) for any CAC among men with high-normal FBG versus normal FBG was 2.19 (95% CI: 1.33-3.58). On further adjustment for risk factors the relationship was slightly attenuated, however remained statistically significant (OR = 1.78, 95% CI 1.05-3.00, p = 0.03). In sub-stratified analyses high-normal FBG was associated with CAC among men without MS (OR: 1.99, 95% CI: 1.04-3.78) and with MS (OR: 2.12, 95% CI: 0.95-4.80). Similar relations with high-normal FBG were observed among individuals classified low risk (OR: 2.34, 95% CI: 1.14-4.83) as well intermediate high-risk men (OR: 1.95, 95% CI: 0.99-3.86) by Framingham risk score (FRS), respectively. Conclusions: : Fasting blood glucose in the upper normal range appears to be associated with the presence of CAC in apparently non-diabetic Brazilian men.
KW - Coronary artery calcification
KW - Electron-beam tomography
KW - Fasting blood glucose
KW - Subclinical atherosclerosis
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U2 - 10.1016/j.atherosclerosis.2007.05.025
DO - 10.1016/j.atherosclerosis.2007.05.025
M3 - Article
C2 - 17606259
AN - SCOPUS:36048998230
SN - 0021-9150
VL - 195
SP - e155-e160
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -