TY - JOUR
T1 - High Intercorrelations Among Urinary Outputs of Norepinephrine and Its Major Metabolites
T2 - A Replication in Depressed Patients and Controls
AU - Roy, Alec
AU - Guthrie, Sally
AU - Karoum, Farouk
AU - Pickar, David
AU - Linnoila, Markku
PY - 1988
Y1 - 1988
N2 - We examined the intercorrelations among urinary outputs of norepinephrine (NE) and its three major metabolites in unipolar depressed patients (n = 28) and normal controls (n = 24). Among the depressed patients, levels of NE correlated with normetanephrine (NM), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA), and VMA correlated with NM and MHPG. In the total group of depressed and control subjects (n = 52), the sum of NE and its major metabolites correlated with urinary outputs of NE, NM, MHPG, and VMA. These highly significant correlations among urinary outputs of NE and its major metabolites replicate a previous report of strong correlations among these same four urinary substances in a smaller group of depressed patients.
AB - We examined the intercorrelations among urinary outputs of norepinephrine (NE) and its three major metabolites in unipolar depressed patients (n = 28) and normal controls (n = 24). Among the depressed patients, levels of NE correlated with normetanephrine (NM), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA), and VMA correlated with NM and MHPG. In the total group of depressed and control subjects (n = 52), the sum of NE and its major metabolites correlated with urinary outputs of NE, NM, MHPG, and VMA. These highly significant correlations among urinary outputs of NE and its major metabolites replicate a previous report of strong correlations among these same four urinary substances in a smaller group of depressed patients.
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U2 - 10.1001/archpsyc.1988.01800260072009
DO - 10.1001/archpsyc.1988.01800260072009
M3 - Article
C2 - 3337613
AN - SCOPUS:0023834881
SN - 0003-990X
VL - 45
SP - 158
EP - 161
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 2
ER -