High-dose naloxone affects task performance in normal subjects

Robert M. Cohen, Martin R. Cohen, Herbert Weingartner, David Pickar, Dennis L. Murphy

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Increasing intravenous doses of naloxone (0.3 mg/kg, 1 mg/kg, and 2 mg/kg) were administered to normal subjects. Naloxone at 2 mg/kg, but not at lower doses, impaired aspects of memory as measured by a verbal learning task which assessed the direct free recall and recognition of presented versus nonpresented words of a single category (effortful processing) and the monitoring of the frequency of such presentations (automatic processing). At the same time "working" memory was left unaffected. The results suggest a role for the opioid system in some memory processes in man.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalPsychiatry Research
Issue number2
StatePublished - 1983
Externally publishedYes


  • automatic processing
  • frequency
  • memory
  • Naloxone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • General Psychology


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