High-dose monotherapy in treatment of intractable seizures

Ronald P. Lesser, Charles E. Pippenger, Hans Lüders, Dudley S. Dinner

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures. Treatment with a single drug was equal to or better than polypharmacy, but only a few patients became free of seizures. Toxicity was mild and associated with higher total plasma levels after polypharmacy. Free fractions ranged from 0.14 to 0.30 for carbamazepine and from 0.60 to 0.13 for phenytoin. Toxicity was associated with free phenytoin levels above 3 μg/ml; there was no clear relationship between free carbamazepine level and toxicity.

Original languageEnglish (US)
Pages (from-to)707-711
Number of pages5
Issue number6
StatePublished - Jun 1984
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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