High-dose isoflavones do not improve metabolic and inflammatory parameters in androgen-deprived men with prostate cancer

Joshua K. Napora, Ryan G. Short, Denis C. Muller, Olga D. Carlson, Juliana O. Odetunde, Xiaoqiang Xu, Michael Carducci, Thomas G. Travison, Marcello Maggio, Josephine M. Egan, Shehzad Basaria

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The profound hypogonadism that occurs with androgen deprivation therapy (ADT) for prostate cancer (PCa) results in complications such as diabetes and metabolic syndrome that predispose to cardiovascular disease. Because phytoestrogens have been associated with an improvement in metabolic parameters, we evaluated their role in men undergoing ADT. Our objective was to evaluate the effects of high-dose isoflavones on metabolic and inflammatory parameters in men undergoing ADT. This was a randomized, double-blind, placebo-controlled, 12-week pilot study. Participants were randomly assigned to receive 20 g of soy protein containing 160 mg of total isoflavones vs taste-matched placebo (20 g whole milk protein). The study was conducted at a tertiary care center in the United States. Thirty-threemen (isoflavones=17, placebo=16) undergoing ADT for PCa completed this pilot study. Mean age in the 2 groups was 69 years and the majority of men were Caucasians. Mean duration of ADT in both groups was approximately 2 years (P = .70). The 2 groups were well matched at baseline. After 12 weeks of intervention, there was no significant difference in either metabolic or inflammatory parameters between the 2 groups. We found that high-dose isoflavones over a course of 12 weeks do not improve metabolic or inflammatory parameters in androgen-deprived men.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalJournal of andrology
Issue number1
StatePublished - Jan 2011


  • Androgen deprivation
  • Inflammation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology


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