High-density lipoprotein metabolism and endothelial function

Charles J. Lowenstein, Scott J. Cameron

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Purpose of Review: High-density lipoprotein (HDL) protects against atherosclerosis, transporting cholesterol from peripheral cells to the liver, where it is excreted into the bile. However, HDL also has prominent vascular protective effects. Recent Findings: Recent studies have uncovered mechanisms through which HDL decreases vascular inflammation, boosts nitric oxide production, and inhibits thrombosis. The discovery that dysfunctional HDL can also have proinflammatory effects has uncovered a new aspect of HDL biology. Summary: Low-density lipoprotein is the primary target for drug therapy of dyslipidemias. Drugs that increase HDL also affect additional metabolic pathways. Development of selective drugs targeting key aspects of HDL metabolism may enable us to alter the composition of HDL and inhibit atherogenesis.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Issue number2
StatePublished - Apr 2010
Externally publishedYes


  • Apolipoprotein A-I
  • Hyperlipidemia
  • Inflammation
  • Macrophage
  • Nitric oxide

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics


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