High basal expression of zif268 in cortex is dependent on intact noradrenergic system

Ratan V. Bhat; Jay M. Baraban

doi:10.1016/0922-4106(92)90165-R

High basal expression of zif268 in cortex is dependent on intact noradrenergic system

Ratan V. Bhat, Jay M. Baraban

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The transcription factor Zif268 displays high basal levels of expression in cortex that appear to be dependent on physiological synaptic activity. We report that selective lesions of the noradrenergic system induced by DSP4 markedly suppress basal zif268 mRNA levels in cortex. Accordingly, the noradrenergic system which projects extensively to the cortex and is tonically active may play a key role in maintaining normal patterns of gene expression in target neurons.

Original language	English (US)
Pages (from-to)	447-448
Number of pages	2
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	227
Issue number	4
DOIs	https://doi.org/10.1016/0922-4106(92)90165-R
State	Published - Dec 1 1992

Keywords

DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)
Locus coeruleus
Transcription factors

ASJC Scopus subject areas

Pharmacology

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10.1016/0922-4106(92)90165-R

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abstract = "The transcription factor Zif268 displays high basal levels of expression in cortex that appear to be dependent on physiological synaptic activity. We report that selective lesions of the noradrenergic system induced by DSP4 markedly suppress basal zif268 mRNA levels in cortex. Accordingly, the noradrenergic system which projects extensively to the cortex and is tonically active may play a key role in maintaining normal patterns of gene expression in target neurons.",

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AU - Baraban, Jay M.

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N2 - The transcription factor Zif268 displays high basal levels of expression in cortex that appear to be dependent on physiological synaptic activity. We report that selective lesions of the noradrenergic system induced by DSP4 markedly suppress basal zif268 mRNA levels in cortex. Accordingly, the noradrenergic system which projects extensively to the cortex and is tonically active may play a key role in maintaining normal patterns of gene expression in target neurons.

AB - The transcription factor Zif268 displays high basal levels of expression in cortex that appear to be dependent on physiological synaptic activity. We report that selective lesions of the noradrenergic system induced by DSP4 markedly suppress basal zif268 mRNA levels in cortex. Accordingly, the noradrenergic system which projects extensively to the cortex and is tonically active may play a key role in maintaining normal patterns of gene expression in target neurons.

KW - DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)

KW - Locus coeruleus

KW - Transcription factors

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High basal expression of zif268 in cortex is dependent on intact noradrenergic system

Abstract

Keywords

ASJC Scopus subject areas

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