Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O2 homeostasis in animals. A molecular basis for O2-regulated expression of the HIF-1α subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Oct 5 2001|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)