HIF-1, O2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus

Gregg L. Semenza

doi:10.1016/S0092-8674(01)00518-9

HIF-1, O₂, and the 3 PHDs: How animal cells signal hypoxia to the nucleus

Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Review article › peer-review

729 Scopus citations

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O₂ homeostasis in animals. A molecular basis for O₂-regulated expression of the HIF-1α subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Cell
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/S0092-8674(01)00518-9
State	Published - Oct 5 2001

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(01)00518-9

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title = "HIF-1, O2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus",

abstract = "Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O2 homeostasis in animals. A molecular basis for O2-regulated expression of the HIF-1α subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.",

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AB - Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O2 homeostasis in animals. A molecular basis for O2-regulated expression of the HIF-1α subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

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HIF-1, O₂, and the 3 PHDs: How animal cells signal hypoxia to the nucleus

Abstract

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