HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Keyphrases

• Hypoxia-inducible factor-1α (HIF-1α) 100%
• Cellular Adaptation 100%
• Pyruvate Dehydrogenase Kinase 4 (PDK4) 100%
• Adaptation to Hypoxia 100%
• Metabolic Switch 100%
• Tricarboxylic Acid Cycle (TCA cycle) 50%
• Hypoxia 25%
• Mitochondria 25%
• Glycolysis 25%
• Shunt 25%
• Lactate 25%
• Metabolism 25%
• Acetyl Coenzyme A (acetyl-CoA) 25%
• ROS Production 25%
• Pyruvate Dehydrogenase 25%
• Glycolysis-related Genes 25%
• Null Cell 25%
• Glucose Metabolite 25%
• Hypoxia-induced Apoptosis 25%
• ATP Production 25%
• ATP Level 25%
• ROS Generation 25%
• Metabolic Adaptation 25%

Biochemistry, Genetics and Molecular Biology

• Pyruvate Dehydrogenase Kinase 100%
• Kinase A 100%
• Adenosine Triphosphate 50%
• Citric Acid Cycle 50%
• Enzyme 25%
• Mitochondrion 25%
• Metabolic Pathway 25%
• Acetyl-CoA 25%
• Metabolite 25%
• Pyruvate Dehydrogenase 25%