HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia

Keyphrases

• Hypoxia Response 100%
• Gene Transcription 100%
• DNA-dependent Protein Kinase (DNA-PK) 100%
• Hypoxia-inducible factor-1α (HIF-1α) 100%
• RNA Polymerase II (RNAPII) 100%
• TRIM28 100%
• Polymerase II 50%
• Hypoxia Response Element 33%
• Breast Cancer 16%
• Transcription Factor 16%
• Molecular Mechanism 16%
• Breast Cancer Cells 16%
• Drug Effects 16%
• Drug Target 16%
• Homeostasis 16%
• O2 Availability 16%
• Hypoxic Condition 16%
• Metazoan 16%
• Transcription Elongation 16%
• HIF Target Genes 16%
• Large Subunit 16%
• Anticancer Effect 16%
• Heterotrimer 16%
• Cellular Hypoxia 16%
• Cyclin-dependent Kinase 9 (CDK9) 16%
• Serine 2 16%
• Negative Elongation Factor 16%

Biochemistry, Genetics and Molecular Biology

• Protein Kinases 100%
• Genetic Transcription 100%
• Hypoxia Inducible Factor 1 100%
• RNA Polymerase II 100%
• Transcription 50%
• Polymerase 50%
• Response Element 33%
• Serine 33%
• C-Terminus 16%
• Transcription Factors 16%
• Cancer Cell 16%
• Homeostasis 16%
• Anticancer 16%
• Animal 16%
• Transcription Elongation 16%
• Drug Targeting 16%
• Cell Hypoxia 16%
• Negative Elongation Factor 16%