HIF-1 and tumor progression: Pathophysiology and therapeutics

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877 Scopus citations


Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed HIF-1β subunit and an oxygen- and growth-factor-regulated HIF-1α subunit. In xenografts, tumor growth and angiogenesis are correlated with HIF-1 expression. In human cancers, HIF-1α is overexpressed as a result of intratumoral hypoxia and genetic alterations affecting key oncogenes and tumor suppressor genes. HIF-1α overexpression in biopsies of brain, breast, cervical, esophageal, oropharyngeal and ovarian cancers is correlated with treatment failure and mortality. Increased HIF-1 activity promotes tumor progression, and inhibition of HIF-1 could represent a novel approach to cancer therapy.

Original languageEnglish (US)
Pages (from-to)S62-S67
JournalTrends in Molecular Medicine
Issue number4 SUPPL.
StatePublished - Apr 22 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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