Heterozygous VMAT2 knockout mice display prolonged QT intervals: Possible contributions to sudden death

Kaori Itokawa; Ichiro Sora; Charles W. Schindler; Masanari Itokawa; Nobuyuki Takahashi; George R. Uhl

doi:10.1016/S0169-328X(99)00194-1

Heterozygous VMAT2 knockout mice display prolonged QT intervals: Possible contributions to sudden death

Kaori Itokawa, Ichiro Sora, Charles W. Schindler, Masanari Itokawa, Nobuyuki Takahashi, George R. Uhl

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Heterozygous knockout (KO) mice with half of wild-type levels of expression of the vesicular monoamine transporter (VMAT2) can suddenly die in midlife. To seek mechanisms for this sudden death, we have examined electrocardiogram (ECG) data telemetered from freely-moving heterozygote and wild-type littermate mice. Many ECG parameters were indistinguishable in mice of these two strains. However, heterozygous mice displayed prolonged QT intervals. These findings provide likely contributions to differences in vulnerability to lethal arrhythmias in these animals, and a candidate gene for contributions to human interindividual differences in vulnerability to cardiac arrhythmias.

Original language	English (US)
Pages (from-to)	354-357
Number of pages	4
Journal	Molecular Brain Research
Volume	71
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(99)00194-1
State	Published - Aug 25 1999

Keywords

Electrocardiogram
Prolonged QT
Telemetry
Transgenic mouse
Vesicular monoamine transporter 2

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(99)00194-1

Cite this

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title = "Heterozygous VMAT2 knockout mice display prolonged QT intervals: Possible contributions to sudden death",

abstract = "Heterozygous knockout (KO) mice with half of wild-type levels of expression of the vesicular monoamine transporter (VMAT2) can suddenly die in midlife. To seek mechanisms for this sudden death, we have examined electrocardiogram (ECG) data telemetered from freely-moving heterozygote and wild-type littermate mice. Many ECG parameters were indistinguishable in mice of these two strains. However, heterozygous mice displayed prolonged QT intervals. These findings provide likely contributions to differences in vulnerability to lethal arrhythmias in these animals, and a candidate gene for contributions to human interindividual differences in vulnerability to cardiac arrhythmias.",

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T2 - Possible contributions to sudden death

AU - Itokawa, Kaori

AU - Sora, Ichiro

AU - Schindler, Charles W.

AU - Itokawa, Masanari

AU - Takahashi, Nobuyuki

AU - Uhl, George R.

PY - 1999/8/25

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AB - Heterozygous knockout (KO) mice with half of wild-type levels of expression of the vesicular monoamine transporter (VMAT2) can suddenly die in midlife. To seek mechanisms for this sudden death, we have examined electrocardiogram (ECG) data telemetered from freely-moving heterozygote and wild-type littermate mice. Many ECG parameters were indistinguishable in mice of these two strains. However, heterozygous mice displayed prolonged QT intervals. These findings provide likely contributions to differences in vulnerability to lethal arrhythmias in these animals, and a candidate gene for contributions to human interindividual differences in vulnerability to cardiac arrhythmias.

KW - Electrocardiogram

KW - Prolonged QT

KW - Telemetry

KW - Transgenic mouse

KW - Vesicular monoamine transporter 2

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Heterozygous VMAT2 knockout mice display prolonged QT intervals: Possible contributions to sudden death

Abstract

Keywords

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