Abstract
While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.
Original language | English (US) |
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Pages (from-to) | 1828-1831 |
Number of pages | 4 |
Journal | Infection and immunity |
Volume | 72 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases