Heterogeneity in Alzheimer's disease

Marshal F. Folstein

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The phenotype of Alzheimer's disease is variable. Age of onset, cognitive features, and neuropathology differ case to case. In some cases the differences are due to variable expression and others to genetic heterogeneity. Present evidence suggests four types of Alzheimer's disease: early and late onset autosomal dominant forms, trisomy 21, and phenocopies.

Original languageEnglish (US)
Pages (from-to)434-435
Number of pages2
JournalNeurobiology of Aging
Issue number5
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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