Heterogeneity in Alzheimer's disease

Marshal F. Folstein

doi:10.1016/0197-4580(89)90086-9

Heterogeneity in Alzheimer's disease

Marshal F. Folstein

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The phenotype of Alzheimer's disease is variable. Age of onset, cognitive features, and neuropathology differ case to case. In some cases the differences are due to variable expression and others to genetic heterogeneity. Present evidence suggests four types of Alzheimer's disease: early and late onset autosomal dominant forms, trisomy 21, and phenocopies.

Original language	English (US)
Pages (from-to)	434-435
Number of pages	2
Journal	Neurobiology of Aging
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/0197-4580(89)90086-9
State	Published - Jan 1 1989

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(89)90086-9

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title = "Heterogeneity in Alzheimer's disease",

abstract = "The phenotype of Alzheimer's disease is variable. Age of onset, cognitive features, and neuropathology differ case to case. In some cases the differences are due to variable expression and others to genetic heterogeneity. Present evidence suggests four types of Alzheimer's disease: early and late onset autosomal dominant forms, trisomy 21, and phenocopies.",

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AB - The phenotype of Alzheimer's disease is variable. Age of onset, cognitive features, and neuropathology differ case to case. In some cases the differences are due to variable expression and others to genetic heterogeneity. Present evidence suggests four types of Alzheimer's disease: early and late onset autosomal dominant forms, trisomy 21, and phenocopies.

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Heterogeneity in Alzheimer's disease

Abstract

ASJC Scopus subject areas

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