Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins

John Nicholas, Keith R. Cameron, Robert W. Honess

Research output: Contribution to journalArticlepeer-review

155 Scopus citations


HERPESVIRUS saimiri (HVS) is a T-lymphotropic gammaherpes-virus which establishes asymptomatic infections in its natural host the squirrel monkey (Saimiri sciureus), but which causes fatal lymphoproliferative diseases in other New World primates1. Sequencing studies show HVS is closely related to the human B-lymphotropic gammaherpesvirus Epstein-Barr virus (EBV)2-4. However, despite the general collinearity between the genomes of HVS and EBV, HVS contains genes not found in EBV or in the genomes of any of the other sequenced herpesviruses5-8. We have identified two genes, occurring in a region of divergence between HVS and EBV, that have cellular homologues. One of these, ECRF3, is homologous to the genes encoding the human cytomegalovirus (HCMV) and cellular G protein-coupled receptor family of proteins9. The other HVS gene, ECLF2, is homologous to the genes encoding cellular cyclins and to our knowledge is the first reported example of a viral cyclin. The presence of G protein-coupled receptor and cyclin homologues in HVS suggests that these genes may be important in the regulation of viral and cellular processes during productive and/or latent infection of host cells, and in particular may be of relevance in the transformation and rapid proliferation of T cells during HVS infections of hosts susceptible to HVS-induced lymphoproliferative diseases.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
Issue number6358
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • General


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