Herpes Simples Virus Type 2 Shedding from Male Circumcision Wounds in Rakai, Uganda

Mary K. Grabowski; Godfrey Kigozi; Ronald H. Gray; Benjamin Armour; Jordyn Manucci; David Serwadda; Andrew D. Redd; Fred Nalugoda; Eshan U. Patel; Maria J. Wawer; Thomas C. Quinn; Aaron A.R. Tobian

doi:10.1093/infdis/jiv259

Herpes Simples Virus Type 2 Shedding from Male Circumcision Wounds in Rakai, Uganda

Mary K. Grabowski, Godfrey Kigozi, Ronald H. Gray, Benjamin Armour, Jordyn Manucci, David Serwadda, Andrew D. Redd, Fred Nalugoda, Eshan U. Patel, Maria J. Wawer, Thomas C. Quinn, Aaron A.R. Tobian

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1 Scopus citations

Abstract

A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.

Original language	English (US)
Pages (from-to)	1613-1617
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	212
Issue number	10
DOIs	https://doi.org/10.1093/infdis/jiv259
State	Published - Nov 15 2015

Keywords

Herpes simplex virus type 2 (HSV-2)
Human immunodeficiency virus (HIV)
Male circumcision
Penile viral shedding
Uganda
Viral load

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jiv259

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@article{008bb13e44cd4acd80fc6329d7050f3e,

title = "Herpes Simples Virus Type 2 Shedding from Male Circumcision Wounds in Rakai, Uganda",

abstract = "A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.",

keywords = "Herpes simplex virus type 2 (HSV-2), Human immunodeficiency virus (HIV), Male circumcision, Penile viral shedding, Uganda, Viral load",

author = "Grabowski, {Mary K.} and Godfrey Kigozi and Gray, {Ronald H.} and Benjamin Armour and Jordyn Manucci and David Serwadda and Redd, {Andrew D.} and Fred Nalugoda and Patel, {Eshan U.} and Wawer, {Maria J.} and Quinn, {Thomas C.} and Tobian, {Aaron A.R.}",

note = "Funding Information: Financial support. This work was supported by the Bill and Melinda Gates Foundation (grant 22006.03 for sample collection); the Doris Duke Charitable Foundation (grant 2011036 for laboratory work and Clinician Scientist Development awards to M. K. G. and A. A. R. T.); the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, and the Fogarty International Center (grant 1D43TWOO9578-01); and Funding Information: the National Institutes of Health (grants T32AI102 supported M. K. G. and 1K23AI093152-01A1 to A. A. R. T.). Potential conflicts of interest. All authors: No reported conflicts.",

year = "2015",

month = nov,

day = "15",

doi = "10.1093/infdis/jiv259",

language = "English (US)",

volume = "212",

pages = "1613--1617",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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T1 - Herpes Simples Virus Type 2 Shedding from Male Circumcision Wounds in Rakai, Uganda

AU - Grabowski, Mary K.

AU - Kigozi, Godfrey

AU - Gray, Ronald H.

AU - Armour, Benjamin

AU - Manucci, Jordyn

AU - Serwadda, David

AU - Redd, Andrew D.

AU - Nalugoda, Fred

AU - Patel, Eshan U.

AU - Wawer, Maria J.

AU - Quinn, Thomas C.

AU - Tobian, Aaron A.R.

N1 - Funding Information: Financial support. This work was supported by the Bill and Melinda Gates Foundation (grant 22006.03 for sample collection); the Doris Duke Charitable Foundation (grant 2011036 for laboratory work and Clinician Scientist Development awards to M. K. G. and A. A. R. T.); the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, and the Fogarty International Center (grant 1D43TWOO9578-01); and Funding Information: the National Institutes of Health (grants T32AI102 supported M. K. G. and 1K23AI093152-01A1 to A. A. R. T.). Potential conflicts of interest. All authors: No reported conflicts.

PY - 2015/11/15

Y1 - 2015/11/15

N2 - A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.

AB - A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.

KW - Herpes simplex virus type 2 (HSV-2)

KW - Human immunodeficiency virus (HIV)

KW - Male circumcision

KW - Penile viral shedding

KW - Uganda

KW - Viral load

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DO - 10.1093/infdis/jiv259

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C2 - 25943201

AN - SCOPUS:84977980564

SN - 0022-1899

VL - 212

SP - 1613

EP - 1617

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 10

ER -

Herpes Simples Virus Type 2 Shedding from Male Circumcision Wounds in Rakai, Uganda

Abstract

Keywords

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