Herpes Simples Virus Type 2 Shedding from Male Circumcision Wounds in Rakai, Uganda

Mary K. Grabowski, Godfrey Kigozi, Ronald H. Gray, Benjamin Armour, Jordyn Manucci, David Serwadda, Andrew D. Redd, Fred Nalugoda, Eshan U. Patel, Maria J. Wawer, Thomas C. Quinn, Aaron A.R. Tobian

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1 Scopus citations


A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.

Original languageEnglish (US)
Pages (from-to)1613-1617
Number of pages5
JournalJournal of Infectious Diseases
Issue number10
StatePublished - Nov 15 2015


  • Herpes simplex virus type 2 (HSV-2)
  • Human immunodeficiency virus (HIV)
  • Male circumcision
  • Penile viral shedding
  • Uganda
  • Viral load

ASJC Scopus subject areas

  • General Medicine


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