Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

Ingrid M. Outschoorn; Noel R. Rose; C. Lynne Burek; Tim W. Jones; Ian R. Mackay; Merrill J. Rowley

doi:10.1080/08916930500128248

Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

Ingrid M. Outschoorn, Noel R. Rose, C. Lynne Burek, Tim W. Jones, Ian R. Mackay, Merrill J. Rowley

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The genetic control of the levels of autoantibodies has rarely been examined. We examined the heritability of autoantibodies to glutamic acid decarboxylase (GAD65) in type 1 diabetes, and to thyroglobulin (Tg) in chronic lymphocytic thyroiditis and thyrotoxicosis, using regression of offspring on midparent (ROMP) methods. Levels of autoantibodies in patients and their parents were significantly correlated in thyrotoxicosis (R² = 0.569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative.

Original language	English (US)
Pages (from-to)	325-326
Number of pages	2
Journal	Autoimmunity
Volume	38
Issue number	4
DOIs	https://doi.org/10.1080/08916930500128248
State	Published - Jun 2005

Keywords

Autoantibodies
Autoimmune thyroiditis
GAD/diabetes
Gene environment interactions
Heritability
Thyroglobulin

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1080/08916930500128248

Cite this

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abstract = "The genetic control of the levels of autoantibodies has rarely been examined. We examined the heritability of autoantibodies to glutamic acid decarboxylase (GAD65) in type 1 diabetes, and to thyroglobulin (Tg) in chronic lymphocytic thyroiditis and thyrotoxicosis, using regression of offspring on midparent (ROMP) methods. Levels of autoantibodies in patients and their parents were significantly correlated in thyrotoxicosis (R2 = 0.569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative.",

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AU - Outschoorn, Ingrid M.

AU - Rose, Noel R.

AU - Burek, C. Lynne

AU - Jones, Tim W.

AU - Mackay, Ian R.

AU - Rowley, Merrill J.

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Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

Abstract

Keywords

ASJC Scopus subject areas

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