Heritability of ambulatory and office blood pressure in the Swiss population

Heba Alwan; Georg Ehret; Belen Ponte; Menno Pruijm; Daniel Ackermann; Idris Guessous; Jan A. Staessen; Kei Asayama; Zoltán Kutalik; Philippe Vuistiner; Fred Paccaud; Antoinette Pechere-Bertschi; Markus Mohaupt; Bruno Vogt; Pierre Yves Martin; Michel Burnier; Murielle Bochud

doi:10.1097/HJH.0000000000000681

Heritability of ambulatory and office blood pressure in the Swiss population

Heba Alwan, Georg Ehret, Belen Ponte, Menno Pruijm, Daniel Ackermann, Idris Guessous, Jan A. Staessen, Kei Asayama, Zoltán Kutalik, Philippe Vuistiner, Fred Paccaud, Antoinette Pechere-Bertschi, Markus Mohaupt, Bruno Vogt, Pierre Yves Martin, Michel Burnier, Murielle Bochud

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. Results: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m 2, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37±0.07, 0.26±0.07, and 0.29±0.07 for 24-h BP; 0.39±0.07, 0.28±0.07, and 0.27±0.07 for day BP; and 0.25±0.07, 0.20±0.07, and 0.30±0.07 for night BP, respectively (all P<0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21±0.08, 0.25±0.08, and 0.18±0.07 (all P<0.01). Conclusions: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.

Original language	English (US)
Pages (from-to)	2061-2067
Number of pages	7
Journal	Journal of hypertension
Volume	33
Issue number	10
DOIs	https://doi.org/10.1097/HJH.0000000000000681
State	Published - 2015

Keywords

ambulatory blood pressure
cross-sectional
heritability
population

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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10.1097/HJH.0000000000000681

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Alwan, H., Ehret, G., Ponte, B., Pruijm, M., Ackermann, D., Guessous, I., Staessen, J. A., Asayama, K., Kutalik, Z., Vuistiner, P., Paccaud, F., Pechere-Bertschi, A., Mohaupt, M., Vogt, B., Martin, P. Y., Burnier, M., & Bochud, M. (2015). Heritability of ambulatory and office blood pressure in the Swiss population. Journal of hypertension, 33(10), 2061-2067. https://doi.org/10.1097/HJH.0000000000000681

Alwan, H, Ehret, G, Ponte, B, Pruijm, M, Ackermann, D, Guessous, I, Staessen, JA, Asayama, K, Kutalik, Z, Vuistiner, P, Paccaud, F, Pechere-Bertschi, A, Mohaupt, M, Vogt, B, Martin, PY, Burnier, M & Bochud, M 2015, 'Heritability of ambulatory and office blood pressure in the Swiss population', Journal of hypertension, vol. 33, no. 10, pp. 2061-2067. https://doi.org/10.1097/HJH.0000000000000681

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title = "Heritability of ambulatory and office blood pressure in the Swiss population",

abstract = "Background: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. Results: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m 2, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37±0.07, 0.26±0.07, and 0.29±0.07 for 24-h BP; 0.39±0.07, 0.28±0.07, and 0.27±0.07 for day BP; and 0.25±0.07, 0.20±0.07, and 0.30±0.07 for night BP, respectively (all P<0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21±0.08, 0.25±0.08, and 0.18±0.07 (all P<0.01). Conclusions: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.",

keywords = "ambulatory blood pressure, cross-sectional, heritability, population",

author = "Heba Alwan and Georg Ehret and Belen Ponte and Menno Pruijm and Daniel Ackermann and Idris Guessous and Staessen, {Jan A.} and Kei Asayama and Zolt{\'a}n Kutalik and Philippe Vuistiner and Fred Paccaud and Antoinette Pechere-Bertschi and Markus Mohaupt and Bruno Vogt and Martin, {Pierre Yves} and Michel Burnier and Murielle Bochud",

note = "Publisher Copyright: {\textcopyright} 2015 Wolters Kluwer Health, Inc.",

year = "2015",

doi = "10.1097/HJH.0000000000000681",

language = "English (US)",

volume = "33",

pages = "2061--2067",

journal = "Journal of hypertension",

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TY - JOUR

T1 - Heritability of ambulatory and office blood pressure in the Swiss population

AU - Alwan, Heba

AU - Ehret, Georg

AU - Ponte, Belen

AU - Pruijm, Menno

AU - Ackermann, Daniel

AU - Guessous, Idris

AU - Staessen, Jan A.

AU - Asayama, Kei

AU - Kutalik, Zoltán

AU - Vuistiner, Philippe

AU - Paccaud, Fred

AU - Pechere-Bertschi, Antoinette

AU - Mohaupt, Markus

AU - Vogt, Bruno

AU - Martin, Pierre Yves

AU - Burnier, Michel

AU - Bochud, Murielle

PY - 2015

Y1 - 2015

N2 - Background: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. Results: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m 2, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37±0.07, 0.26±0.07, and 0.29±0.07 for 24-h BP; 0.39±0.07, 0.28±0.07, and 0.27±0.07 for day BP; and 0.25±0.07, 0.20±0.07, and 0.30±0.07 for night BP, respectively (all P<0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21±0.08, 0.25±0.08, and 0.18±0.07 (all P<0.01). Conclusions: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.

AB - Background: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. Results: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m 2, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37±0.07, 0.26±0.07, and 0.29±0.07 for 24-h BP; 0.39±0.07, 0.28±0.07, and 0.27±0.07 for day BP; and 0.25±0.07, 0.20±0.07, and 0.30±0.07 for night BP, respectively (all P<0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21±0.08, 0.25±0.08, and 0.18±0.07 (all P<0.01). Conclusions: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.

KW - ambulatory blood pressure

KW - cross-sectional

KW - heritability

KW - population

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DO - 10.1097/HJH.0000000000000681

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AN - SCOPUS:84960098692

SN - 0263-6352

VL - 33

SP - 2061

EP - 2067

JO - Journal of hypertension

JF - Journal of hypertension

IS - 10

ER -

Heritability of ambulatory and office blood pressure in the Swiss population

Abstract

Keywords

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