Hereditary cancer syndromes in Latino populations: Genetic characterization and surveillance guidelines

Marcia Cruz-Correa, Julyann Pérez-Mayoral, Julie Dutil, Miguel Echenique, Rafael Mosquera, Keila Rivera-Román, Sharee Umpierre, Segundo Rodriguez-Quilichini, Maria Gonzalez-Pons, Myrta I. Olivera, Sherly Pardo

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network's screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients.

Original languageEnglish (US)
Article number3
JournalHereditary Cancer in Clinical Practice
Issue number1
StatePublished - Jan 21 2017
Externally publishedYes


  • Genetic counseling
  • Genetic testing
  • Germline mutations
  • Hereditary cancer
  • Hispanics

ASJC Scopus subject areas

  • Oncology
  • Genetics(clinical)


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