TY - JOUR
T1 - Hereditary cancer syndromes in Latino populations
T2 - Genetic characterization and surveillance guidelines
AU - Cruz-Correa, Marcia
AU - Pérez-Mayoral, Julyann
AU - Dutil, Julie
AU - Echenique, Miguel
AU - Mosquera, Rafael
AU - Rivera-Román, Keila
AU - Umpierre, Sharee
AU - Rodriguez-Quilichini, Segundo
AU - Gonzalez-Pons, Maria
AU - Olivera, Myrta I.
AU - Pardo, Sherly
PY - 2017/1/21
Y1 - 2017/1/21
N2 - Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network's screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients.
AB - Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network's screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients.
KW - Genetic counseling
KW - Genetic testing
KW - Germline mutations
KW - Hereditary cancer
KW - Hispanics
UR - http://www.scopus.com/inward/record.url?scp=85010021986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010021986&partnerID=8YFLogxK
U2 - 10.1186/s13053-017-0063-z
DO - 10.1186/s13053-017-0063-z
M3 - Review article
C2 - 28127413
AN - SCOPUS:85010021986
SN - 1731-2302
VL - 15
JO - Hereditary Cancer in Clinical Practice
JF - Hereditary Cancer in Clinical Practice
IS - 1
M1 - 3
ER -