Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair

Rosalinda Madonna; Gregg Rokosh; Raffaele De Caterina; Roberto Bolli

doi:10.1007/s00395-010-0102-7

Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair

Rosalinda Madonna, Gregg Rokosh, Raffaele De Caterina, Roberto Bolli

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

The adult heart has been recently recognized as a self-renewing organ that contains a pool of committed resident cardiac stem cells (CSCs) and cardiac progenitor cells (CPCs). These adult CSCs and CPCs can be induced by cytokines and growth factors to migrate, differentiate, and proliferate in situ and potentially replace lost cardiomyocytes. Ligand-receptor systems, such as the tyrosine kinase receptor mesenchymal-epithelial transition factor (Met) and its ligand hepatocyte growth factor (HGF), are potential candidates for boosting migration, engraftment and commitment of CSCs. Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration.

Original language	English (US)
Pages (from-to)	443-452
Number of pages	10
Journal	Basic Research in Cardiology
Volume	105
Issue number	4
DOIs	https://doi.org/10.1007/s00395-010-0102-7
State	Published - Jul 2010
Externally published	Yes

Keywords

Cardiac progenitor cells
Cardiac repair
Cardiac stem cells
Cell-based therapy
Gene therapy
Hepatocyte growth factor

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1007/s00395-010-0102-7

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title = "Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair",

abstract = "The adult heart has been recently recognized as a self-renewing organ that contains a pool of committed resident cardiac stem cells (CSCs) and cardiac progenitor cells (CPCs). These adult CSCs and CPCs can be induced by cytokines and growth factors to migrate, differentiate, and proliferate in situ and potentially replace lost cardiomyocytes. Ligand-receptor systems, such as the tyrosine kinase receptor mesenchymal-epithelial transition factor (Met) and its ligand hepatocyte growth factor (HGF), are potential candidates for boosting migration, engraftment and commitment of CSCs. Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration.",

keywords = "Cardiac progenitor cells, Cardiac repair, Cardiac stem cells, Cell-based therapy, Gene therapy, Hepatocyte growth factor",

author = "Rosalinda Madonna and Gregg Rokosh and {De Caterina}, Raffaele and Roberto Bolli",

note = "Funding Information: The original studies here reported were supported by National Institutes of Health grants R01 HL55757, HL-70897, HL-76794, and HL78825 (to R. Bolli); and grants by the Italian Ministry of Research and Scientific Research and the Istituto Italiano Ricerche Cardiovascolari (to Prof. R. De Caterina).",

year = "2010",

month = jul,

doi = "10.1007/s00395-010-0102-7",

language = "English (US)",

volume = "105",

pages = "443--452",

journal = "Basic Research in Cardiology",

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T1 - Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair

AU - Madonna, Rosalinda

AU - Rokosh, Gregg

AU - De Caterina, Raffaele

AU - Bolli, Roberto

N1 - Funding Information: The original studies here reported were supported by National Institutes of Health grants R01 HL55757, HL-70897, HL-76794, and HL78825 (to R. Bolli); and grants by the Italian Ministry of Research and Scientific Research and the Istituto Italiano Ricerche Cardiovascolari (to Prof. R. De Caterina).

PY - 2010/7

Y1 - 2010/7

N2 - The adult heart has been recently recognized as a self-renewing organ that contains a pool of committed resident cardiac stem cells (CSCs) and cardiac progenitor cells (CPCs). These adult CSCs and CPCs can be induced by cytokines and growth factors to migrate, differentiate, and proliferate in situ and potentially replace lost cardiomyocytes. Ligand-receptor systems, such as the tyrosine kinase receptor mesenchymal-epithelial transition factor (Met) and its ligand hepatocyte growth factor (HGF), are potential candidates for boosting migration, engraftment and commitment of CSCs. Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration.

AB - The adult heart has been recently recognized as a self-renewing organ that contains a pool of committed resident cardiac stem cells (CSCs) and cardiac progenitor cells (CPCs). These adult CSCs and CPCs can be induced by cytokines and growth factors to migrate, differentiate, and proliferate in situ and potentially replace lost cardiomyocytes. Ligand-receptor systems, such as the tyrosine kinase receptor mesenchymal-epithelial transition factor (Met) and its ligand hepatocyte growth factor (HGF), are potential candidates for boosting migration, engraftment and commitment of CSCs. Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration.

KW - Cardiac progenitor cells

KW - Cardiac repair

KW - Cardiac stem cells

KW - Cell-based therapy

KW - Gene therapy

KW - Hepatocyte growth factor

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U2 - 10.1007/s00395-010-0102-7

DO - 10.1007/s00395-010-0102-7

M3 - Review article

C2 - 20393738

AN - SCOPUS:77953120266

SN - 0300-8428

VL - 105

SP - 443

EP - 452

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

IS - 4

ER -

Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair

Abstract

Keywords

ASJC Scopus subject areas

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