Hepatobiliary complications of ulcerative colitis

Mark Lupinetti, Denis Mehigan, John L. Cameron

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The records of 202 patients with chronic ulcerative colitis seen over a 12 year period were reviewed. Over one half (55 percent) were found to have liver function test abnormalities. These abnormalities correlated with the extent and severity of ulcerative colitis but not with the duration of the disease. Eight patients (4 percent) developed cirrhosis and four required portasystemic decompression for bleeding varices. Four patients (2 percent) developed biliary tract complications. Two patients were diagnosed as having sclerosing cholangitis, and two patients developed carcinoma of the extrahepatic biliary tree. Three of these four patients had whole colon involvement, but all four had mild clinical disease. It is concluded that the hepatobiliary complications of ulcerative colitis are the most frequent and serious extracolonic manifestations of the disease.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalThe American Journal of Surgery
Issue number1
StatePublished - Jan 1980
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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