Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group

Sharon Castellino; Andrew Muir; Ami Shah; Sheila Shope; Kevin McMullen; Kathy Ruble; Ashley Barber; Andrew Davidoff; Melissa M. Hudson

doi:10.1002/pbc.22265

Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group

Sharon Castellino, Andrew Muir, Ami Shah, Sheila Shope, Kevin McMullen, Kathy Ruble, Ashley Barber, Andrew Davidoff, Melissa M. Hudson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.

Original language	English (US)
Pages (from-to)	663-669
Number of pages	7
Journal	Pediatric Blood and Cancer
Volume	54
Issue number	5
DOIs	https://doi.org/10.1002/pbc.22265
State	Published - May 2010

Keywords

Adolescent cancer survivor
Childhood cancer
Hepato-biliary late effects
Screening

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.22265

Cite this

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abstract = "Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.",

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AU - Castellino, Sharon

AU - Muir, Andrew

AU - Shah, Ami

AU - Shope, Sheila

AU - McMullen, Kevin

AU - Ruble, Kathy

AU - Barber, Ashley

AU - Davidoff, Andrew

AU - Hudson, Melissa M.

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AB - Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.

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Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group

Abstract

Keywords

ASJC Scopus subject areas

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