Hepatitis e virus seroprevalence and correlates of anti-HEV IgG antibodies in the Rakai District, Uganda

the Rakai Health Sciences Program

doi:10.1093/infdis/jix610

Hepatitis e virus seroprevalence and correlates of anti-HEV IgG antibodies in the Rakai District, Uganda

the Rakai Health Sciences Program

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A cross-sectional study was conducted of 500 human immunodeficiency virus (HIV)-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and 1 HIV-infected individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (prevalence ratios [PR] = 1.247; 95% confidence interval [CI], 1.071-1.450) and chronic hepatitis B virus infection (PR = 1.377; 95% CI, 1.090-1.738) were associated with HEV seroprevalence. HIV infection status (PR = 0.973; 95% CI, 0.852-1.111) was not associated with HEV seroprevalence. These data suggest there is a large burden of prior exposure to HEV in rural Uganda.

Original language	English (US)
Pages (from-to)	785-789
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	217
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jix610
State	Published - Mar 1 2018

Keywords

HEV seroprevalence
Hepatitis E virus
Rakai
Uganda
Viral hepatitis

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jix610

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title = "Hepatitis e virus seroprevalence and correlates of anti-HEV IgG antibodies in the Rakai District, Uganda",

abstract = "A cross-sectional study was conducted of 500 human immunodeficiency virus (HIV)-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and 1 HIV-infected individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (prevalence ratios [PR] = 1.247; 95% confidence interval [CI], 1.071-1.450) and chronic hepatitis B virus infection (PR = 1.377; 95% CI, 1.090-1.738) were associated with HEV seroprevalence. HIV infection status (PR = 0.973; 95% CI, 0.852-1.111) was not associated with HEV seroprevalence. These data suggest there is a large burden of prior exposure to HEV in rural Uganda.",

keywords = "HEV seroprevalence, Hepatitis E virus, Rakai, Uganda, Viral hepatitis",

author = "{the Rakai Health Sciences Program} and Denali Boon and Redd, {Andrew D.} and Oliver Laeyendecker and Engle, {Ronald E.} and Hanh Nguyen and Ponsiano Ocama and Iga Boaz and Anthony Ndyanabo and Valerian Kiggundu and Reynolds, {Steven J.} and Gray, {Ronald H.} and Wawer, {Maria J.} and Purcell, {Robert H.} and Kirk, {Gregory D.} and Quinn, {Thomas C.} and Lara Stabinski",

note = "Publisher Copyright: {\textcopyright} The 2017 Author(s).",

year = "2018",

month = mar,

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doi = "10.1093/infdis/jix610",

language = "English (US)",

volume = "217",

pages = "785--789",

journal = "Journal of Infectious Diseases",

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T1 - Hepatitis e virus seroprevalence and correlates of anti-HEV IgG antibodies in the Rakai District, Uganda

AU - the Rakai Health Sciences Program

AU - Boon, Denali

AU - Redd, Andrew D.

AU - Laeyendecker, Oliver

AU - Engle, Ronald E.

AU - Nguyen, Hanh

AU - Ocama, Ponsiano

AU - Boaz, Iga

AU - Ndyanabo, Anthony

AU - Kiggundu, Valerian

AU - Reynolds, Steven J.

AU - Gray, Ronald H.

AU - Wawer, Maria J.

AU - Purcell, Robert H.

AU - Kirk, Gregory D.

AU - Quinn, Thomas C.

AU - Stabinski, Lara

PY - 2018/3/1

Y1 - 2018/3/1

N2 - A cross-sectional study was conducted of 500 human immunodeficiency virus (HIV)-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and 1 HIV-infected individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (prevalence ratios [PR] = 1.247; 95% confidence interval [CI], 1.071-1.450) and chronic hepatitis B virus infection (PR = 1.377; 95% CI, 1.090-1.738) were associated with HEV seroprevalence. HIV infection status (PR = 0.973; 95% CI, 0.852-1.111) was not associated with HEV seroprevalence. These data suggest there is a large burden of prior exposure to HEV in rural Uganda.

AB - A cross-sectional study was conducted of 500 human immunodeficiency virus (HIV)-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and 1 HIV-infected individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (prevalence ratios [PR] = 1.247; 95% confidence interval [CI], 1.071-1.450) and chronic hepatitis B virus infection (PR = 1.377; 95% CI, 1.090-1.738) were associated with HEV seroprevalence. HIV infection status (PR = 0.973; 95% CI, 0.852-1.111) was not associated with HEV seroprevalence. These data suggest there is a large burden of prior exposure to HEV in rural Uganda.

KW - HEV seroprevalence

KW - Hepatitis E virus

KW - Rakai

KW - Uganda

KW - Viral hepatitis

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Hepatitis e virus seroprevalence and correlates of anti-HEV IgG antibodies in the Rakai District, Uganda

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Keywords

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