Hemozoin: Oil versus water

John M. Pisciotta; David Sullivan

doi:10.1016/j.parint.2007.09.009

Hemozoin: Oil versus water

John M. Pisciotta, David Sullivan

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Because the quinolines inhibit heme crystallization within the malaria parasite much work has focused on mechanism of formation and inhibition of hemozoin. Here we review the recent evidence for heme crystallization within lipids in diverse parasites and the new implications of a lipid site of crystallization for drug targeting. Within leukocytes hemozoin can generate toxic radical lipid metabolites, which may alter immune function or reduce deformability of uninfected erythrocytes.

Original language	English (US)
Pages (from-to)	89-96
Number of pages	8
Journal	Parasitology International
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/j.parint.2007.09.009
State	Published - Jun 2008

Keywords

Heme crystal
Hemozoin
Lipid
Malaria pigment
Plasmodium
Quinoline
Rhodnius
Schistosoma

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Access to Document

10.1016/j.parint.2007.09.009

Cite this

@article{1fb61ac442144f5a9db9bcc96ab6a014,

title = "Hemozoin: Oil versus water",

abstract = "Because the quinolines inhibit heme crystallization within the malaria parasite much work has focused on mechanism of formation and inhibition of hemozoin. Here we review the recent evidence for heme crystallization within lipids in diverse parasites and the new implications of a lipid site of crystallization for drug targeting. Within leukocytes hemozoin can generate toxic radical lipid metabolites, which may alter immune function or reduce deformability of uninfected erythrocytes.",

keywords = "Heme crystal, Hemozoin, Lipid, Malaria pigment, Plasmodium, Quinoline, Rhodnius, Schistosoma",

author = "Pisciotta, {John M.} and David Sullivan",

note = "Funding Information: D. S. would like to acknowledge the support of the NIH RO1 AI045774 and Abhai Tripathi for a review of manuscript. Rebecca Kent photographed the Anopheles arabiensis mosquito in Macha, Zambia.",

year = "2008",

month = jun,

doi = "10.1016/j.parint.2007.09.009",

language = "English (US)",

volume = "57",

pages = "89--96",

journal = "Parasitology International",

issn = "1383-5769",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Hemozoin

T2 - Oil versus water

AU - Pisciotta, John M.

AU - Sullivan, David

N1 - Funding Information: D. S. would like to acknowledge the support of the NIH RO1 AI045774 and Abhai Tripathi for a review of manuscript. Rebecca Kent photographed the Anopheles arabiensis mosquito in Macha, Zambia.

PY - 2008/6

Y1 - 2008/6

N2 - Because the quinolines inhibit heme crystallization within the malaria parasite much work has focused on mechanism of formation and inhibition of hemozoin. Here we review the recent evidence for heme crystallization within lipids in diverse parasites and the new implications of a lipid site of crystallization for drug targeting. Within leukocytes hemozoin can generate toxic radical lipid metabolites, which may alter immune function or reduce deformability of uninfected erythrocytes.

AB - Because the quinolines inhibit heme crystallization within the malaria parasite much work has focused on mechanism of formation and inhibition of hemozoin. Here we review the recent evidence for heme crystallization within lipids in diverse parasites and the new implications of a lipid site of crystallization for drug targeting. Within leukocytes hemozoin can generate toxic radical lipid metabolites, which may alter immune function or reduce deformability of uninfected erythrocytes.

KW - Heme crystal

KW - Hemozoin

KW - Lipid

KW - Malaria pigment

KW - Plasmodium

KW - Quinoline

KW - Rhodnius

KW - Schistosoma

UR - http://www.scopus.com/inward/record.url?scp=40749135946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40749135946&partnerID=8YFLogxK

U2 - 10.1016/j.parint.2007.09.009

DO - 10.1016/j.parint.2007.09.009

M3 - Review article

C2 - 18373972

AN - SCOPUS:40749135946

SN - 1383-5769

VL - 57

SP - 89

EP - 96

JO - Parasitology International

JF - Parasitology International

IS - 2

ER -

Hemozoin: Oil versus water

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this