Abstract
The tested hypothesis was that ultrasound-induced hemolysis in blood supplemented with a micro-bubble contrast agent varies with ultrasound intensity and pulse duration. Human erythrocytes in autologous plasma containing 3.6% v:v Albunex microspheres were exposed to 1.07-MHz ultrasound pulses of 5 to 1000 μs at SPTP intensities of 0 to 1100 W/cm2. The dependence of hemolysis on the mechanical index (MI) value of the exposures was also examined. Ultrasound-induced hemolysis: (1) was evident at all pulse/intensity combinations; (2) increased generally with increasing pulse duration at constant intensity; and (3) increased with increasing MI at constant pulse duration. For pulses of 10 to 30 μs, ultrasound-induced hemolysis remained low (≤2%) at MI values < approx.2 and increased sharply with further increase in MI; for 5-μs pulses, this abrupt increase in hemolysis was associated with a larger MI (approximately 3).
Original language | English (US) |
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Pages (from-to) | 927-938 |
Number of pages | 12 |
Journal | Ultrasound in Medicine and Biology |
Volume | 22 |
Issue number | 7 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- Albunex microspheres
- Hemolysis
- Pulsed ultrasound bioeffects
ASJC Scopus subject areas
- Biophysics
- Radiological and Ultrasound Technology
- Acoustics and Ultrasonics