Hemispheric asymmetry in behavioral response to D1 and D2 receptor agonists in the nucleus accumbens

Iren Belcheva, Joseph B. Bryer, Sergio E. Starkstein, Marc Honig, Timothy H. Moran, Robert G. Robinson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The present study examined the locomotor response of rats unilateral injections of the mixed D1/D2 agonist apomorphine, the D2 agonist quinpirole, and the D1 agonist SKF 38393 into the left or right nucleus accumbens (NA) of male Sprague-Dawley rats. There were 2 main findings. First, unilateral (left or right) injections of apomorphine, quinpirole, or SKF 38393 all provoked locomotor hyperactivity. The second and more important finding was that, at specific dosages, apomorphine and SKF 38393 injections into the right NA produced significantly more locomotor hyperactivity than identical injections into the left NA. These findings suggest the presence of asymmetries in the NA which may involve quantitative differences in the distribution of D1 and D2 receptors.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalBrain research
Issue number2
StatePublished - Nov 19 1990


  • Asymmetry
  • Dopamine
  • Lateralization
  • Locomotion
  • Nucleus accumbens

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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