Hemispheric asymmetry in behavioral response to D1 and D2 receptor agonists in the nucleus accumbens

Iren Belcheva; Joseph B. Bryer; Sergio E. Starkstein; Marc Honig; Timothy H. Moran; Robert G. Robinson

doi:10.1016/0006-8993(90)91351-G

Hemispheric asymmetry in behavioral response to D₁ and D₂ receptor agonists in the nucleus accumbens

Iren Belcheva, Joseph B. Bryer, Sergio E. Starkstein, Marc Honig, Timothy H. Moran, Robert G. Robinson

School of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The present study examined the locomotor response of rats unilateral injections of the mixed D₁/D₂ agonist apomorphine, the D₂ agonist quinpirole, and the D₁ agonist SKF 38393 into the left or right nucleus accumbens (NA) of male Sprague-Dawley rats. There were 2 main findings. First, unilateral (left or right) injections of apomorphine, quinpirole, or SKF 38393 all provoked locomotor hyperactivity. The second and more important finding was that, at specific dosages, apomorphine and SKF 38393 injections into the right NA produced significantly more locomotor hyperactivity than identical injections into the left NA. These findings suggest the presence of asymmetries in the NA which may involve quantitative differences in the distribution of D₁ and D₂ receptors.

Original language	English (US)
Pages (from-to)	286-291
Number of pages	6
Journal	Brain research
Volume	533
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(90)91351-G
State	Published - Nov 19 1990

Keywords

Asymmetry
Dopamine
Lateralization
Locomotion
Nucleus accumbens

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(90)91351-G

Cite this

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title = "Hemispheric asymmetry in behavioral response to D1 and D2 receptor agonists in the nucleus accumbens",

abstract = "The present study examined the locomotor response of rats unilateral injections of the mixed D1/D2 agonist apomorphine, the D2 agonist quinpirole, and the D1 agonist SKF 38393 into the left or right nucleus accumbens (NA) of male Sprague-Dawley rats. There were 2 main findings. First, unilateral (left or right) injections of apomorphine, quinpirole, or SKF 38393 all provoked locomotor hyperactivity. The second and more important finding was that, at specific dosages, apomorphine and SKF 38393 injections into the right NA produced significantly more locomotor hyperactivity than identical injections into the left NA. These findings suggest the presence of asymmetries in the NA which may involve quantitative differences in the distribution of D1 and D2 receptors.",

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author = "Iren Belcheva and Bryer, {Joseph B.} and Starkstein, {Sergio E.} and Marc Honig and Moran, {Timothy H.} and Robinson, {Robert G.}",

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AU - Bryer, Joseph B.

AU - Starkstein, Sergio E.

AU - Honig, Marc

AU - Moran, Timothy H.

AU - Robinson, Robert G.

PY - 1990/11/19

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