Hemiplegic migraine: Hyperperfusion and abortive therapy with intravenous verapamil

David A. Hsu; Carl E. Stafstrom; Howard A. Rowley; Jane E. Kiff; Douglas A. Dulli

doi:10.1016/j.braindev.2007.05.013

Hemiplegic migraine: Hyperperfusion and abortive therapy with intravenous verapamil

David A. Hsu, Carl E. Stafstrom, Howard A. Rowley, Jane E. Kiff, Douglas A. Dulli

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A 20-year-old female with hemiplegic migraine was treated during an acute attack with intravenous verapamil, which reproducibly resolved the headache within 20 min but did not affect her hemiplegia. Magnetic resonance (MR) and computed tomographic (CT) angiography and perfusion performed during the attack showed vasodilation and hyperperfusion. Cerebral hyperperfusion concurrent with hemiplegia suggests a dissociation between cerebral perfusion and neuronal function in hemiplegic migraine. The beneficial effect of verapamil on headache but not hemiplegia suggests a distinct mechanism for pain and neuronal dysfunction in hemiplegic migraine, with the beneficial effect on pain not due to vasodilation.

Original language	English (US)
Pages (from-to)	86-90
Number of pages	5
Journal	Brain and Development
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.braindev.2007.05.013
State	Published - Jan 2008
Externally published	Yes

Keywords

Cerebral perfusion
Hemiplegic migraine
Intravenous verapamil

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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10.1016/j.braindev.2007.05.013

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abstract = "A 20-year-old female with hemiplegic migraine was treated during an acute attack with intravenous verapamil, which reproducibly resolved the headache within 20 min but did not affect her hemiplegia. Magnetic resonance (MR) and computed tomographic (CT) angiography and perfusion performed during the attack showed vasodilation and hyperperfusion. Cerebral hyperperfusion concurrent with hemiplegia suggests a dissociation between cerebral perfusion and neuronal function in hemiplegic migraine. The beneficial effect of verapamil on headache but not hemiplegia suggests a distinct mechanism for pain and neuronal dysfunction in hemiplegic migraine, with the beneficial effect on pain not due to vasodilation.",

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AU - Stafstrom, Carl E.

AU - Rowley, Howard A.

AU - Kiff, Jane E.

AU - Dulli, Douglas A.

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Hemiplegic migraine: Hyperperfusion and abortive therapy with intravenous verapamil

Abstract

Keywords

ASJC Scopus subject areas

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