Hematogenous histoplasmosis in the immunocompromised child

Walter T. Hughes

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Hematogenous (disseminated) histoplasmosis occurred in 31 of 4158 children with cancer or immune deficiency disorders. Approximately half of the 31 patients had pulmonary lesions, reacted to the histoplasmin skin test, and generated complement-fixing antibodies to Histoplasma capsulatum. In a comparative study delayed hypersensitivity to histoplasmin was demonstrated in 36 (5.7%) of 634 children at the time of diagnosis of cancer. Patients with cancer who were reactive to histoplasmin before treatment were at no greater, and possibly less, risk for hematogenous histoplasmosis than were nonreactors. All of the 27 patients who received treatment for >1 day recovered; three had recurrences that responded to treatment.

Original languageEnglish (US)
Pages (from-to)569-575
Number of pages7
JournalThe Journal of pediatrics
Issue number4
StatePublished - Oct 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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