@article{ae033c9001ab41449d91ccbbe56087e6,
title = "Helminth egg derivatives as proregenerative immunotherapies",
abstract = "The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4expressing T helper cells, eosinophils, and regulatory T cells and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular joint and corneal injury models. These results introduce a regenerative immunotherapy approach using natural helminth derivatives.",
keywords = "biomaterials, helminth, immune response, regenerative medicine, tissue engineering",
author = "Maestas, {David R.} and Liam Chung and Jin Han and Xiaokun Wang and Sommerfeld, {Sven D.} and Kelly, {Sean H.} and Erika Moore and Nguyen, {Helen Hieu} and Mej{\'i}as, {Joscelyn C.} and Pe{\~n}a, {Alexis N.} and Hong Zhang and Hooks, {Joshua S.T.} and Chin, {Alexander F.} and Andorko, {James I.} and Berlinicke, {Cynthia A.} and Kavita Krishnan and Younghwan Choi and Anderson, {Amy E.} and Ronak Mahatme and Christopher Mejia and Marie Eric and Woo, {Ji Won} and Sudipto Ganguly and Zack, {Donald J.} and Liang Zhao and Pearce, {Edward J.} and Franck Housseau and Pardoll, {Drew M.} and Elisseeff, {Jennifer H.}",
note = "Funding Information: to adhere to conventional standards for all studies herein to ensure reproducibility. All S. mansoni eggs, livers, and reagents utilized in this work were obtained courtesy of the Biomedical Research Institute (BRI) (Rockville), a 501 (c) (3) nonprofit research company supported by the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH through the NIH–NIAID, contract: HHSN272201700014I. Funding Information: ACKNOWLEDGMENTS. We thank the BRI of Rockville, Maryland, for providing helminth eggs and SEA-associated resources,contract: HHSN272201700014I,and Christopher A.Moad for technical assistance.Funding: This study was funded by NIH Pioneer Award DP1AR076959 (J.H.E.),Bloomberg~Kimmel Institute (J.H.E.,D.M.P.), Morton Goldberg Professorship (J.H.E.), The Department of Defense, award number W81XWH-19-1-0576 (J.H.E.), The National Eye Institute grant, R01EY029055 (J.H.E.), The NSF Graduate Research Fellowship Program #DGE-1746891 (D.R.M., A.N.P.), The Armed Forces Institute for Regenerative Medicine II award number WFUHS 441081 CF-11 (J.H.E.), The NIH T32 Training Grant 1T32AG058527-01 (J.I.A.), The NIH T32 Training Grant 5T32CA153952-08 (J.I.A.), The NIH K-Award 1KL2TROO1429(E.M.),andTheRhinesRisingStarLarryHenchProfessorship(E.M.). Publisher Copyright: Copyright {\textcopyright} 2023 the Author(s).",
year = "2023",
month = feb,
day = "21",
doi = "10.1073/pnas.2211703120",
language = "English (US)",
volume = "120",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "8",
}