Health-related quality of life and economic burden of prurigo nodularis

Katherine A. Whang, Thomas K. Le, Raveena Khanna, Kyle A. Williams, Youkyung Sophie Roh, Nishadh Sutaria, Justin Choi, Sylvie Gabriel, Rajeev Chavda, Yevgeniy Semenov, Shawn G. Kwatra

Research output: Contribution to journalArticlepeer-review


Background: Prurigo nodularis (PN) is an understudied, pruritic inflammatory skin disease. Little is known about the effect of PN on quality of life and its associated economic burden. Objective: To quantify the impact of PN on quality of life and its economic implications. Methods: A cohort study of PN patients (n = 36) was conducted using the Health Utilities Index Mark 3 questionnaire. Control data from US adults (n = 4187) were obtained from the 2002-2003 Joint Canada/United States Survey of Health. Quality-adjusted life year loss and economic costs were estimated by comparing the Health Utilities Index Mark 3 scores of the PN patients with those of the controls. Results: The PN patients had lower overall health performance compared to the controls, (mean ± SE, 0.52 ± 0.06 vs 0.86 ± 0.003, respectively, P < .001). In multivariable regression, PN was found to be associated with worse health performance (coefficient −0.34, 95% CI [−0.46 to −0.23]), most prominent in the pain subdomain (coefficient −0.24, 95% CI [−0.35 to −0.13]). This correlated to an average of 6.5 lifetime quality-adjusted life years lost per patient, translating to an individual lifetime economic burden of $323,292 and a societal burden of $38.8 billion. Conclusion: These results demonstrate that PN is associated with significant quality-of-life impairment, similar to the level of other chronic systemic conditions. PN is also associated with a substantial individual economic burden, emphasizing the necessity of research on effective treatment options.

Original languageEnglish (US)
Pages (from-to)573-580
Number of pages8
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Mar 2022


  • chronic pruritus
  • disease burden
  • economic burden
  • epidemiology
  • health utility
  • itch
  • prurigo nodularis
  • pruritus
  • quality of life

ASJC Scopus subject areas

  • Dermatology


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