Hats off to 20S proteasome substrate discovery

Taylor R. Church; Anna Brennan; Seth S. Margolis

doi:10.1038/s44320-024-00028-7

Hats off to 20S proteasome substrate discovery

Taylor R. Church, Anna Brennan, Seth S. Margolis

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.

Original language	English (US)
Pages (from-to)	293-295
Number of pages	3
Journal	Molecular systems biology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1038/s44320-024-00028-7
State	Published - Apr 2 2024

ASJC Scopus subject areas

Information Systems
General Immunology and Microbiology
Applied Mathematics
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Computational Theory and Mathematics

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10.1038/s44320-024-00028-7

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abstract = "Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.",

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N2 - Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.

AB - Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.

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Hats off to 20S proteasome substrate discovery

Abstract

ASJC Scopus subject areas

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