Harnessing economic drivers for successful clinical implementation of pharmacogenetic testing

P. A. Deverka, H. L. McLeod

Research output: Contribution to journalComment/debatepeer-review

17 Scopus citations


Before pharmacogenetic (PGx) testing has a major impact on clinical practice, two levels of evidence must be generated. First, studies demonstrating the links between genetic variation and response to medications in defined populations are needed, along with development of valid tests to measure these specific variants. Second, studies should be conducted to evaluate whether PGx testing improves health outcomes for patients and whether the decision to test is cost-effective relative to usual care. This latter set of questions is typically of greatest relevance to clinicians and payers, the ultimate gatekeepers for the clinical integration of pharmacogenetics. To date, nearly all of the research efforts and funding for PGx have been focused on the first set of issues - getting the science right. However, now is the time to increase our research efforts on the second set of issues - to improve the PGx evidence base for both clinical and economic decision making.

Original languageEnglish (US)
Pages (from-to)191-193
Number of pages3
JournalClinical pharmacology and therapeutics
Issue number2
StatePublished - Aug 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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