TY - JOUR
T1 - Hairless triggers reactivation of hair growth by promoting Wnt signaling
AU - Beaudoin, Gerard M.J.
AU - Sisk, Jeanne M.
AU - Coulombe, Pierre A.
AU - Thompson, Catherine C.
PY - 2005/10/11
Y1 - 2005/10/11
N2 - The mammalian hair cycle involves periodic regeneration of a tiny organ, the hair follicle, through a stem-cell-mediated process. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for hair follicle regeneration, but its role in this process is unknown. Here, we demonstrate that transgenic expression of HR in progenitor keratinocytes rescues follicle regeneration in Hr-/- mice. We show that expression of Wise, a modulator of Wnt signaling, is repressed by HR in these cells, coincident with the timing of follicle regeneration. This work links HR and Wnt function, providing a model in which HR regulates the precise timing of Wnt signaling required for hair follicle regeneration.
AB - The mammalian hair cycle involves periodic regeneration of a tiny organ, the hair follicle, through a stem-cell-mediated process. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for hair follicle regeneration, but its role in this process is unknown. Here, we demonstrate that transgenic expression of HR in progenitor keratinocytes rescues follicle regeneration in Hr-/- mice. We show that expression of Wise, a modulator of Wnt signaling, is repressed by HR in these cells, coincident with the timing of follicle regeneration. This work links HR and Wnt function, providing a model in which HR regulates the precise timing of Wnt signaling required for hair follicle regeneration.
KW - Corepressor
KW - Nuclear receptor
KW - Skin
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U2 - 10.1073/pnas.0507609102
DO - 10.1073/pnas.0507609102
M3 - Article
C2 - 16195376
AN - SCOPUS:26844523484
SN - 0027-8424
VL - 102
SP - 14653
EP - 14658
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 41
ER -