Hair dye use is not associated with risk for bladder cancer: Evidence from a case-control study in Spain

Manolis Kogevinas, Francisco Fernandez, Montserrat Garcia-Closas, Adonina Tardon, Reina Garcia-Closas, Consol Serra, Alfredo Carrato, Gemma Castano-Vinyals, Meredith Yeager, Stephen J. Chanock, Josep Lloreta, Nathaniel Rothman, Francisco X. Real, Mustafa Dosemeci, Nuria Malats, Debra Silverman

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


An increased bladder cancer risk has been suggested among users of hair dyes. We evaluated this association among females in a hospital-based case-control study in Spain (152 female incident cases, 166 female controls). The effect of hair dye use was also evaluated among potentially susceptible subgroups defined by NAT1, NAT2, CYP1A2, GSTM1, GSTT1 and GSTP1 genotypes. Use of any hair dye (OR = 0.8, CI 0.5-1.4) or of permanent hair dyes (OR = 0.8, CI 0.5-1.5) was not associated with increased risk. Small non-significant increases in risks were observed in a lagged analysis that ignores exposures within ten years of diagnosis (OR = 1.3, CI 0.8-2.2). No trend in risk with increasing exposure was seen for duration of use, average use or cumulative use. None of the polymorphisms examined significantly modified the hair dye associated risk. Overall, this study does not support an association between hair dye use and bladder cancer.

Original languageEnglish (US)
Pages (from-to)1448-1454
Number of pages7
JournalEuropean Journal of Cancer
Issue number10
StatePublished - Jul 2006
Externally publishedYes


  • Aromatic amines
  • Bladder cancer
  • Case-control study
  • Hair dyes
  • SNPs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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