TY - JOUR
T1 - Hair dye use is not associated with risk for bladder cancer
T2 - Evidence from a case-control study in Spain
AU - Kogevinas, Manolis
AU - Fernandez, Francisco
AU - Garcia-Closas, Montserrat
AU - Tardon, Adonina
AU - Garcia-Closas, Reina
AU - Serra, Consol
AU - Carrato, Alfredo
AU - Castano-Vinyals, Gemma
AU - Yeager, Meredith
AU - Chanock, Stephen J.
AU - Lloreta, Josep
AU - Rothman, Nathaniel
AU - Real, Francisco X.
AU - Dosemeci, Mustafa
AU - Malats, Nuria
AU - Silverman, Debra
N1 - Funding Information:
This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics and by grants from the Plan Nacional SAF2001-0427, FIS C03/10 and FIS G03/174, (Spanish Government biomedical research programs). We thank Ana Alfaro from IMIM, Cristina Arias from the University of Oviedo, Bob Saal from Westat and Leslie Carroll from IMS for their support in study and data management.
PY - 2006/7
Y1 - 2006/7
N2 - An increased bladder cancer risk has been suggested among users of hair dyes. We evaluated this association among females in a hospital-based case-control study in Spain (152 female incident cases, 166 female controls). The effect of hair dye use was also evaluated among potentially susceptible subgroups defined by NAT1, NAT2, CYP1A2, GSTM1, GSTT1 and GSTP1 genotypes. Use of any hair dye (OR = 0.8, CI 0.5-1.4) or of permanent hair dyes (OR = 0.8, CI 0.5-1.5) was not associated with increased risk. Small non-significant increases in risks were observed in a lagged analysis that ignores exposures within ten years of diagnosis (OR = 1.3, CI 0.8-2.2). No trend in risk with increasing exposure was seen for duration of use, average use or cumulative use. None of the polymorphisms examined significantly modified the hair dye associated risk. Overall, this study does not support an association between hair dye use and bladder cancer.
AB - An increased bladder cancer risk has been suggested among users of hair dyes. We evaluated this association among females in a hospital-based case-control study in Spain (152 female incident cases, 166 female controls). The effect of hair dye use was also evaluated among potentially susceptible subgroups defined by NAT1, NAT2, CYP1A2, GSTM1, GSTT1 and GSTP1 genotypes. Use of any hair dye (OR = 0.8, CI 0.5-1.4) or of permanent hair dyes (OR = 0.8, CI 0.5-1.5) was not associated with increased risk. Small non-significant increases in risks were observed in a lagged analysis that ignores exposures within ten years of diagnosis (OR = 1.3, CI 0.8-2.2). No trend in risk with increasing exposure was seen for duration of use, average use or cumulative use. None of the polymorphisms examined significantly modified the hair dye associated risk. Overall, this study does not support an association between hair dye use and bladder cancer.
KW - Aromatic amines
KW - Bladder cancer
KW - Case-control study
KW - Hair dyes
KW - SNPs
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U2 - 10.1016/j.ejca.2006.02.009
DO - 10.1016/j.ejca.2006.02.009
M3 - Article
C2 - 16740387
AN - SCOPUS:33745167997
SN - 0959-8049
VL - 42
SP - 1448
EP - 1454
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 10
ER -