HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

John W. McDonald; John Uckele; Faye S. Silverstein; Michael V. Johnston

doi:10.1016/0304-3940(89)90349-2

HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

John W. McDonald, John Uckele, Faye S. Silverstein, Michael V. Johnston

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against N-methyl-d-aspartate (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.

Original language	English (US)
Pages (from-to)	167-170
Number of pages	4
Journal	Neuroscience Letters
Volume	104
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(89)90349-2
State	Published - Sep 25 1989

Keywords

MK-801
N-Methyl-d-aspartate
Neuroprotection
Neurotoxicity
Phencyclidine
Rat brain
Strychnine-insensitive glycine receptor

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(89)90349-2

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title = "HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage",

abstract = "The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against N-methyl-d-aspartate (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.",

keywords = "MK-801, N-Methyl-d-aspartate, Neuroprotection, Neurotoxicity, Phencyclidine, Rat brain, Strychnine-insensitive glycine receptor",

author = "McDonald, {John W.} and John Uckele and Silverstein, {Faye S.} and Johnston, {Michael V.}",

year = "1989",

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AU - McDonald, John W.

AU - Uckele, John

AU - Silverstein, Faye S.

AU - Johnston, Michael V.

PY - 1989/9/25

Y1 - 1989/9/25

N2 - The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against N-methyl-d-aspartate (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.

AB - The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against N-methyl-d-aspartate (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.

KW - MK-801

KW - N-Methyl-d-aspartate

KW - Neuroprotection

KW - Neurotoxicity

KW - Phencyclidine

KW - Rat brain

KW - Strychnine-insensitive glycine receptor

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JF - Neuroscience Letters

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ER -

HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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