H 2S signalling through protein sulfhydration and beyond

Research output: Contribution to journalReview articlepeer-review

501 Scopus citations


Hydrogen sulfide (H 2S) has recently emerged as a mammalian gaseous messenger molecule, akin to nitric oxide and carbon monoxide. H 2S is predominantly formed from Cys or its derivatives by the enzymes cystathionine β-synthase and cystathionine Î 3-lyase. One of the mechanisms by which H 2S signals is by sulfhydration of reactive Cys residues in target proteins. Although analogous to protein nitrosylation, sulfhydration is substantially more prevalent and usually increases the catalytic activity of targeted proteins. Physiological actions of sulfhydration include the regulation of inflammation and endoplasmic reticulum stress signalling as well as of vascular tension.

Original languageEnglish (US)
Pages (from-to)499-507
Number of pages9
JournalNature Reviews Molecular Cell Biology
Issue number8
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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