Gut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids

Sepideh Gharaie; Sanjeev Noel; Hamid Rabb

doi:10.1159/000508984

Gut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids

Sepideh Gharaie, Sanjeev Noel, Hamid Rabb

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.

Original language	English (US)
Pages (from-to)	662-664
Number of pages	3
Journal	Nephron
Volume	144
Issue number	12
DOIs	https://doi.org/10.1159/000508984
State	Published - Dec 2020

Keywords

Acute kidney injury
Gut microbiota
Ischemia reperfusion
Short-chain fatty acids
T cells

ASJC Scopus subject areas

Physiology
Nephrology
Physiology (medical)
Urology

Access to Document

10.1159/000508984

Cite this

@article{3f1ef433b00143089166e336fc2499f9,

title = "Gut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids",

abstract = "Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.",

keywords = "Acute kidney injury, Gut microbiota, Ischemia reperfusion, Short-chain fatty acids, T cells",

author = "Sepideh Gharaie and Sanjeev Noel and Hamid Rabb",

note = "Funding Information: Contribution from the AKI and CRRT 2020 Symposium at the 25th International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA, USA, February 24–27, 2020. This symposium was supported in part by the NIDDK-funded University of Alabama at Birmingham-University of California San Diego O{\textquoteright}Brien Center for Acute Kidney Injury Research (P30DK079337). Publisher Copyright: {\textcopyright} 2020 ",

year = "2020",

month = dec,

doi = "10.1159/000508984",

language = "English (US)",

volume = "144",

pages = "662--664",

journal = "Nephron",

issn = "1660-8151",

publisher = "S. Karger AG",

number = "12",

}

TY - JOUR

T1 - Gut Microbiome and AKI

T2 - Roles of the Immune System and Short-Chain Fatty Acids

AU - Gharaie, Sepideh

AU - Noel, Sanjeev

AU - Rabb, Hamid

N1 - Funding Information: Contribution from the AKI and CRRT 2020 Symposium at the 25th International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA, USA, February 24–27, 2020. This symposium was supported in part by the NIDDK-funded University of Alabama at Birmingham-University of California San Diego O’Brien Center for Acute Kidney Injury Research (P30DK079337). Publisher Copyright: © 2020

PY - 2020/12

Y1 - 2020/12

N2 - Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.

AB - Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.

KW - Acute kidney injury

KW - Gut microbiota

KW - Ischemia reperfusion

KW - Short-chain fatty acids

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=85089295934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85089295934&partnerID=8YFLogxK

U2 - 10.1159/000508984

DO - 10.1159/000508984

M3 - Review article

C2 - 32721962

AN - SCOPUS:85089295934

SN - 1660-8151

VL - 144

SP - 662

EP - 664

JO - Nephron

JF - Nephron

IS - 12

ER -

Gut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this