Guinea pig herpes simplex keratitis treated with a lymphocyte extract

Gilbert Smolin, Khalid Tabbara, Masao Okumoto

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A lymphocyte extract was prepared from lymph nodes that had been excised from guinea pigs subjected to foot-pad injections of complete Freund's adjuvant and herpes simplex antigen. Clinical and virologic studies demonstrated that the topical application of the extract was capable of ameliorating the course of an experimentally induced herpes simplex keratitis in other guinea pigs and of reducing the virus titer in the affected corneas. In these respects there was a highly significant difference between the lymphocyte-treated-group of animals and two control groups. No conclusions as to long-term effects are implied.

Original languageEnglish (US)
Pages (from-to)921-925
Number of pages5
JournalAmerican Journal of Ophthalmology
Issue number6
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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