TY - JOUR
T1 - Hormônio do crescimento ou somatotrófico
T2 - novas perspectivas na deficiência isolada de GH a partir da descrição da mutação no gene do receptor do GHRH nos indivíduos da cidade de Itabaianinha, Brasil.
AU - Souza, Anita Hermínia O.
AU - Salvatori, Roberto
AU - Martinelli, Carlos E.
AU - Carvalho, Walter M.O.
AU - Menezes, Carlos A.
AU - Barretto, Elenilde S.de A.
AU - Barreto Filho, José A.S.
AU - Alcântara, Marta R.S.de
AU - Oliveira, Carla R.P.
AU - Alcântara, Paula R.S.de
AU - Ramalho, Roberto J.R.
AU - Oliveira, Hélio A.
AU - Lima, Ivana B.de
AU - Carneiro, Jamille N.
AU - Santos, Marcos M.
AU - Gill, Matthew S.
AU - Clayton, Peter E.
AU - Oliveira, Manuel H.A.
PY - 2004/6
Y1 - 2004/6
N2 - In addition to stimulating body growth, growth or somatotrophic hormone plays an important role in metabolism, body composition, lipid profile, cardiovascular status and longevity. Its control is multiregulated by hormones, metabolites and hypothalamic peptides. Obtained data of the isolated growth hormone deficiency (IGHD) after the description of the IVS1+1G-->A GHRH receptor gene mutation in individuals of Itabaianinha County are reviewed. New perspectives about the growth hormone resistance model, the importance of GHRH in the control of GH secretion, the frequency of GHRH-R gene mutations, the diagnostic relevance of IGF-I and the metabolic, cardiovascular and quality of life findings are approached.
AB - In addition to stimulating body growth, growth or somatotrophic hormone plays an important role in metabolism, body composition, lipid profile, cardiovascular status and longevity. Its control is multiregulated by hormones, metabolites and hypothalamic peptides. Obtained data of the isolated growth hormone deficiency (IGHD) after the description of the IVS1+1G-->A GHRH receptor gene mutation in individuals of Itabaianinha County are reviewed. New perspectives about the growth hormone resistance model, the importance of GHRH in the control of GH secretion, the frequency of GHRH-R gene mutations, the diagnostic relevance of IGF-I and the metabolic, cardiovascular and quality of life findings are approached.
UR - http://www.scopus.com/inward/record.url?scp=17844383264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17844383264&partnerID=8YFLogxK
U2 - 10.1590/s0004-27302004000300013
DO - 10.1590/s0004-27302004000300013
M3 - Article
C2 - 15640904
AN - SCOPUS:17844383264
SN - 0004-2730
VL - 48
SP - 406
EP - 413
JO - Arquivos brasileiros de endocrinologia e metabologia
JF - Arquivos brasileiros de endocrinologia e metabologia
IS - 3
ER -