Growth-factor enhancement of compromised gut function following massive small-bowel resection

Marshall Z. Schwartz; Yoshifumi Kato; Dahong Yu; Jeff R. Lukish

Growth-factor enhancement of compromised gut function following massive small-bowel resection

Marshall Z. Schwartz, Yoshifumi Kato, Dahong Yu, Jeff R. Lukish

Research output: Contribution to journal › Article › peer-review

Abstract

Our laboratory has shown that epidermal growth factor (EGF) and hepatocyte growth factor (HGF) can improve the function of normal rat small intestine. This study was designed to evaluate the role of these growth factors on the residual small intestine following massive (80%) small bowel resection. Our data demonstrate that EGF and HGF can enhance intestinal substrate absorption and mucosal mass beyond that which occurs with intestinal adaptation. These growth factors may be beneficial in the management of children with short bowel syndrome.

Original language	English (US)
Pages (from-to)	174-175
Number of pages	2
Journal	Pediatric Surgery International
Volume	16
Issue number	3
State	Published - Mar 2000
Externally published	Yes

Keywords

Epidermal growth factor
Growth factor
Hepatocyte growth factor
Intestinal function
Intestinal proliferation
Short bowel syndrome

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Our laboratory has shown that epidermal growth factor (EGF) and hepatocyte growth factor (HGF) can improve the function of normal rat small intestine. This study was designed to evaluate the role of these growth factors on the residual small intestine following massive (80%) small bowel resection. Our data demonstrate that EGF and HGF can enhance intestinal substrate absorption and mucosal mass beyond that which occurs with intestinal adaptation. These growth factors may be beneficial in the management of children with short bowel syndrome.",

keywords = "Epidermal growth factor, Growth factor, Hepatocyte growth factor, Intestinal function, Intestinal proliferation, Short bowel syndrome",

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AU - Yu, Dahong

AU - Lukish, Jeff R.

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AB - Our laboratory has shown that epidermal growth factor (EGF) and hepatocyte growth factor (HGF) can improve the function of normal rat small intestine. This study was designed to evaluate the role of these growth factors on the residual small intestine following massive (80%) small bowel resection. Our data demonstrate that EGF and HGF can enhance intestinal substrate absorption and mucosal mass beyond that which occurs with intestinal adaptation. These growth factors may be beneficial in the management of children with short bowel syndrome.

KW - Epidermal growth factor

KW - Growth factor

KW - Hepatocyte growth factor

KW - Intestinal function

KW - Intestinal proliferation

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ER -

Growth-factor enhancement of compromised gut function following massive small-bowel resection

Abstract

Keywords

ASJC Scopus subject areas

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