TY - JOUR
T1 - Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure
AU - Rosenberg, Brian J.
AU - Hirano, Michio
AU - Quinzii, Catarina M.
AU - Colantuoni, Elizabeth
AU - Needham, Dale M.
AU - Lederer, David J.
AU - Baldwin, Matthew R.
N1 - Funding Information:
Funding Dr Baldwin is supported by NIH grant K23 AG045660, a faculty research fellowship from the Columbia University Aging Center, and the Columbia University Irving Institute (NIH grant UL1 TR001873). Dr Quinzii and Dr Hirano are supported by NIH grant P01 HD080642. Dr Hirano is also supported by NIH grant U54 NS078059. Dr Lederer is supported by NIH grants R01 HL103676, R01 HL137234 and K24 HL131937.
Publisher Copyright:
© Author(s) (or their employer(s)) 2019.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Muscle mitochondrial dysfunction is implicated in intensive care unit-acquired weakness, but there is no serum biomarker of muscle mitochondrial function for critical illness survivors. Higher serum growth differentiation factor-15 (GDF-15) is a biomarker of inherited mitochondrial myopathy disease and is associated with mortality in several age-related diseases. Among 142 older (age ≥ 65 years) survivors of acute respiratory failure, we found that higher serum GDF-15 measured during the week prior to hospital discharge was cross-sectionally associated with weaker diaphragm, limb and hand-grip strength, and longitudinally associated with lower rates of functional recovery over 6 months, independent of age, sex, pre-existing disability, comorbidity, frailty, Acute Physiology and Chronic Health Evaluation II scores and concurrent interleukin-6 levels.
AB - Muscle mitochondrial dysfunction is implicated in intensive care unit-acquired weakness, but there is no serum biomarker of muscle mitochondrial function for critical illness survivors. Higher serum growth differentiation factor-15 (GDF-15) is a biomarker of inherited mitochondrial myopathy disease and is associated with mortality in several age-related diseases. Among 142 older (age ≥ 65 years) survivors of acute respiratory failure, we found that higher serum GDF-15 measured during the week prior to hospital discharge was cross-sectionally associated with weaker diaphragm, limb and hand-grip strength, and longitudinally associated with lower rates of functional recovery over 6 months, independent of age, sex, pre-existing disability, comorbidity, frailty, Acute Physiology and Chronic Health Evaluation II scores and concurrent interleukin-6 levels.
KW - Critical Care
KW - Not Applicable
KW - Pulmonary Rehabilitation
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U2 - 10.1136/thoraxjnl-2019-213621
DO - 10.1136/thoraxjnl-2019-213621
M3 - Article
C2 - 31534031
AN - SCOPUS:85072525875
SN - 0040-6376
VL - 74
SP - 1099
EP - 1101
JO - Thorax
JF - Thorax
IS - 11
ER -